255146

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type V Classification (family/domain) ghoTS/ghoT-GhoS
Location 4686702..4687199 Replicon chromosome
Accession NZ_CP103479
Organism Escherichia coli strain 4621

Toxin (Protein)


Gene name ghoT Uniprot ID L4JJG6
Locus tag M5T46_RS22305 Protein ID WP_001173343.1
Coordinates 4686702..4686875 (-) Length 58 a.a.

Antitoxin (Protein)


Gene name ghoS Uniprot ID L4JK92
Locus tag M5T46_RS22310 Protein ID WP_000398619.1
Coordinates 4686903..4687199 (-) Length 99 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T46_RS22295 (4683372) 4683372..4684829 + 1458 WP_000856827.1 dipeptide/tripeptide permease DtpC -
M5T46_RS22300 (4685066) 4685066..4686583 + 1518 WP_000003806.1 lysine--tRNA ligase -
M5T46_RS22305 (4686702) 4686702..4686875 - 174 WP_001173343.1 type V toxin-antitoxin system toxin GhoT Toxin
M5T46_RS22310 (4686903) 4686903..4687199 - 297 WP_000398619.1 type V toxin-antitoxin system endoribonuclease antitoxin GhoS Antitoxin
M5T46_RS22315 (4687426) 4687426..4687698 - 273 WP_000405647.1 GNAT family N-acetyltransferase -
M5T46_RS22320 (4687710) 4687710..4687940 - 231 WP_000373291.1 4Fe-4S mono-cluster protein YjdI -
M5T46_RS22325 (4688121) 4688121..4689752 + 1632 WP_001216481.1 sensor histidine kinase -
M5T46_RS22330 (4689749) 4689749..4690468 + 720 WP_000611288.1 two-component system response regulator DcuR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin GhoT/OrtT

(4-57)

Antitoxin

Endoribonuclease antitoxin GhoS

(5-94)


Sequences

Toxin        


Download         Length: 58 a.a.        Molecular weight: 6555.06 Da        Isoelectric Point: 10.2288

>T255146 WP_001173343.1 NZ_CP103479:c4686875-4686702 [Escherichia coli]
MALFSKILIFYVIGVNISFVIIWFISHEKTHIRLLSAFLVGITWPMSLPVALLFSLF

Download         Length: 174 bp

Antitoxin


Download         Length: 99 a.a.        Molecular weight: 11467.97 Da        Isoelectric Point: 4.1705

>AT255146 WP_000398619.1 NZ_CP103479:c4687199-4686903 [Escherichia coli]
MEGKNKFNTYVVSFDYPSSYSSVFLRLRSLMYDMNFSSIVADEYGIPRQLNENSFAITTSLAASEIEDLIRLKCLDLPDI
DFDLNIMTVDDYFRQFYK

Download         Length: 297 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A7U9QI41

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBH6

References