Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) chpSB/PRK09812-ChpS
Location 4591606..4592201 Replicon chromosome
Accession NZ_CP103479
Organism Escherichia coli strain 4621

Toxin (Protein)


Gene name chpB Uniprot ID V0SXT4
Locus tag M5T46_RS21820 Protein ID WP_000239581.1
Coordinates 4591606..4591956 (-) Length 117 a.a.

Antitoxin (Protein)


Gene name chpS Uniprot ID V0YZQ7
Locus tag M5T46_RS21825 Protein ID WP_001223206.1
Coordinates 4591950..4592201 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T46_RS21800 (4587051) 4587051..4588073 - 1023 WP_024176215.1 ABC transporter permease -
M5T46_RS21805 (4588087) 4588087..4589589 - 1503 WP_001095668.1 sugar ABC transporter ATP-binding protein -
M5T46_RS21810 (4589731) 4589731..4590687 - 957 WP_000265933.1 galactofuranose ABC transporter substrate-binding protein YtfQ -
M5T46_RS21815 (4590997) 4590997..4591527 + 531 WP_000055075.1 inorganic diphosphatase -
M5T46_RS21820 (4591606) 4591606..4591956 - 351 WP_000239581.1 endoribonuclease toxin ChpB Toxin
M5T46_RS21825 (4591950) 4591950..4592201 - 252 WP_001223206.1 type II toxin-antitoxin system ChpS family antitoxin Antitoxin
M5T46_RS21830 (4592413) 4592413..4592754 - 342 WP_001219160.1 gamma-glutamylcyclotransferase -
M5T46_RS21835 (4592757) 4592757..4596536 - 3780 WP_000060869.1 autotransporter assembly complex protein TamB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(8-114)

Antitoxin

SpoVT-AbrB domain

(6-49)


Sequences

Toxin        


Download         Length: 117 a.a.        Molecular weight: 12453.41 Da        Isoelectric Point: 6.2206

>T255145 WP_000239581.1 NZ_CP103479:c4591956-4591606 [Escherichia coli]
MVKKSEFERGDIVLVGFDPASGHEQQGAGRPALVLSVQAFNQLGMTLVAPITQGGNFARYAGFSVPLHCEEGDVHGVVLV
NQVRMMDLRARLAKRIGLAAGEVVEEALLRLQAVVE

Download         Length: 351 bp

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9303.62 Da        Isoelectric Point: 4.6509

>AT255145 WP_001223206.1 NZ_CP103479:c4592201-4591950 [Escherichia coli]
MRITIKKWGNSSGMVIPNVVMKELNLRPGQSVEAQVSNNQLILTPISRRYSLDELLAQCDMNATELSEQDVWGKSTPAGD
EIW

Download         Length: 252 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0SXT4

Antitoxin

Source ID Structure
AlphaFold DB V0YZQ7

References