255142

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) sanaTA/AbiEii-DUF6088
Location 4466603..4467938 Replicon chromosome
Accession NZ_CP103479
Organism Escherichia coli strain 4621

Toxin (Protein)


Gene name sanaT Uniprot ID V0YQY2
Locus tag M5T46_RS21240 Protein ID WP_000342498.1
Coordinates 4466603..4467550 (-) Length 316 a.a.

Antitoxin (Protein)


Gene name sanaA Uniprot ID E0J2C6
Locus tag M5T46_RS21245 Protein ID WP_000152741.1
Coordinates 4467543..4467938 (-) Length 132 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T46_RS21215 (4462456) 4462456..4463172 + 717 WP_001295734.1 N-acetylneuraminic acid outer membrane channel NanC -
M5T46_RS21220 (4463192) 4463192..4464298 + 1107 WP_001328295.1 N-acetylneuraminate epimerase -
M5T46_RS21225 (4464363) 4464363..4465343 + 981 WP_000991420.1 sialate O-acetylesterase -
M5T46_RS21230 (4465351) 4465351..4466001 - 651 WP_001037973.1 HNH endonuclease -
M5T46_RS21235 (4466138) 4466138..4466281 + 144 Protein_4159 HNH endonuclease -
M5T46_RS21240 (4466603) 4466603..4467550 - 948 WP_000342498.1 nucleotidyl transferase AbiEii/AbiGii toxin family protein Toxin
M5T46_RS21245 (4467543) 4467543..4467938 - 396 WP_000152741.1 DUF6088 family protein Antitoxin
M5T46_RS21250 (4468008) 4468008..4468841 - 834 WP_001192747.1 DUF4942 domain-containing protein -
M5T46_RS21255 (4468953) 4468953..4469294 - 342 WP_000691792.1 TA system toxin CbtA family protein -
M5T46_RS21260 (4469325) 4469325..4469660 - 336 WP_000939436.1 type IV toxin-antitoxin system YeeU family antitoxin -
M5T46_RS21265 (4469660) 4469660..4470133 - 474 WP_001292743.1 DNA repair protein RadC -
M5T46_RS21270 (4470163) 4470163..4470981 - 819 WP_001046747.1 DUF932 domain-containing protein -
M5T46_RS21275 (4471218) 4471218..4472171 - 954 WP_000290408.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Genomic island - fimC / fimI / fimA / fimE / fimB 4456927..4486423 29496


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Nucleotidyl transferase AbiEii toxin, Type IV TA system

(38-303)

Antitoxin

Protein of unknown function DUF6088

(7-108)


Sequences

Toxin        


Download         Length: 316 a.a.        Molecular weight: 35616.84 Da        Isoelectric Point: 4.9737

>T255142 WP_000342498.1 NZ_CP103479:c4467550-4466603 [Escherichia coli]
MDDLTTLFSEVADALGIESVAIVEKDHYIVELLQLLKPLVFDTHQLVFAGGTALAKSGVALNRMSEDVDIKLVPKDAFQA
LSRTQRKNTRKEIVQAVSSAIASSGVFNFDDDYPKVTRDEYRYNDIPVRYPQRVVQAPCLRPFIRLELMEAKLLEPSELR
DIHSLVTGITGKAAIVSAFPCATIISTQAEKLVAMLRRTAAVVRDVERFDDASLVRHIYDTNCIVETSHVDMSLLVDFVQ
QTIEQDIQRYGNQYPQFCASPVDELKMGLDELANNPLYQMRYQQFVSPMVYGERKITWDEVYSRFRSLALAILNA

Download         Length: 948 bp

Antitoxin


Download         Length: 132 a.a.        Molecular weight: 14619.93 Da        Isoelectric Point: 11.6915

>AT255142 WP_000152741.1 NZ_CP103479:c4467938-4467543 [Escherichia coli]
MTIKARIQSRLKRSKRYVFTRDDFKDIAGYDQVGRVLRELVREGQLLKVGYGVYTKARRNGITGKVMPAAPGGSSAVIVE
TLERLKVRYRFAGATQAYNSGTSTQIPASPEIKTPRRFKRVLSVGNSRLNG

Download         Length: 396 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0YQY2

Antitoxin

Source ID Structure
AlphaFold DB A0A1L4ZXD4

References