Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3841832..3842450 Replicon chromosome
Accession NZ_CP103479
Organism Escherichia coli strain 4621

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T46_RS18355 Protein ID WP_001291435.1
Coordinates 3842232..3842450 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T46_RS18350 Protein ID WP_000344800.1
Coordinates 3841832..3842206 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T46_RS18340 (3836921) 3836921..3838114 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T46_RS18345 (3838137) 3838137..3841286 + 3150 WP_001132480.1 efflux RND transporter permease AcrB -
M5T46_RS18350 (3841832) 3841832..3842206 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T46_RS18355 (3842232) 3842232..3842450 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T46_RS18360 (3842622) 3842622..3843173 + 552 WP_000102573.1 maltose O-acetyltransferase -
M5T46_RS18365 (3843289) 3843289..3843759 + 471 WP_001328420.1 YlaC family protein -
M5T46_RS18370 (3843923) 3843923..3845473 + 1551 WP_001445674.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T46_RS18375 (3845515) 3845515..3845868 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5T46_RS18385 (3846247) 3846247..3846558 + 312 WP_000409905.1 MGMT family protein -
M5T46_RS18390 (3846589) 3846589..3847161 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255138 WP_001291435.1 NZ_CP103479:3842232-3842450 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255138 WP_000344800.1 NZ_CP103479:3841832-3842206 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References