Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2632671..2634259 | Replicon | chromosome |
Accession | NZ_CP103479 | ||
Organism | Escherichia coli strain 4621 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | V0Z3Q2 |
Locus tag | M5T46_RS12635 | Protein ID | WP_001125418.1 |
Coordinates | 2632937..2634259 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | - |
Locus tag | M5T46_RS12630 | Protein ID | WP_001327997.1 |
Coordinates | 2632671..2632937 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M5T46_RS12630 (2632671) | 2632671..2632937 | + | 267 | WP_001327997.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
M5T46_RS12635 (2632937) | 2632937..2634259 | + | 1323 | WP_001125418.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
M5T46_RS12640 (2634658) | 2634658..2635557 | - | 900 | WP_001057776.1 | LysR family transcriptional regulator | - |
M5T46_RS12645 (2635696) | 2635696..2636004 | + | 309 | WP_001221046.1 | hypothetical protein | - |
M5T46_RS12650 (2636013) | 2636013..2636702 | + | 690 | WP_000801313.1 | type 1 glutamine amidotransferase domain-containing protein | - |
M5T46_RS12655 (2636776) | 2636776..2637723 | + | 948 | WP_000854796.1 | aldo/keto reductase | - |
M5T46_RS12660 (2637826) | 2637826..2637981 | + | 156 | WP_001327998.1 | hypothetical protein | - |
M5T46_RS12665 (2637941) | 2637941..2638360 | + | 420 | WP_001327999.1 | amidohydrolase family protein | - |
M5T46_RS12670 (2638350) | 2638350..2638502 | + | 153 | WP_001322417.1 | amidohydrolase family protein | - |
M5T46_RS12675 (2638653) | 2638653..2639225 | + | 573 | WP_000789912.1 | NAD(P)H-dependent oxidoreductase | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49316.95 Da Isoelectric Point: 8.5823
>T255135 WP_001125418.1 NZ_CP103479:2632937-2634259 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|