Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2632671..2634259 Replicon chromosome
Accession NZ_CP103479
Organism Escherichia coli strain 4621

Toxin (Protein)


Gene name hipA Uniprot ID V0Z3Q2
Locus tag M5T46_RS12635 Protein ID WP_001125418.1
Coordinates 2632937..2634259 (+) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID -
Locus tag M5T46_RS12630 Protein ID WP_001327997.1
Coordinates 2632671..2632937 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T46_RS12630 (2632671) 2632671..2632937 + 267 WP_001327997.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
M5T46_RS12635 (2632937) 2632937..2634259 + 1323 WP_001125418.1 type II toxin-antitoxin system serine/threonine protein kinase toxin HipA Toxin
M5T46_RS12640 (2634658) 2634658..2635557 - 900 WP_001057776.1 LysR family transcriptional regulator -
M5T46_RS12645 (2635696) 2635696..2636004 + 309 WP_001221046.1 hypothetical protein -
M5T46_RS12650 (2636013) 2636013..2636702 + 690 WP_000801313.1 type 1 glutamine amidotransferase domain-containing protein -
M5T46_RS12655 (2636776) 2636776..2637723 + 948 WP_000854796.1 aldo/keto reductase -
M5T46_RS12660 (2637826) 2637826..2637981 + 156 WP_001327998.1 hypothetical protein -
M5T46_RS12665 (2637941) 2637941..2638360 + 420 WP_001327999.1 amidohydrolase family protein -
M5T46_RS12670 (2638350) 2638350..2638502 + 153 WP_001322417.1 amidohydrolase family protein -
M5T46_RS12675 (2638653) 2638653..2639225 + 573 WP_000789912.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(149-401)

Antitoxin

Cro/C1-type helix-turn-helix domain

(14-69)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 49316.95 Da        Isoelectric Point: 8.5823

>T255135 WP_001125418.1 NZ_CP103479:2632937-2634259 [Escherichia coli]
MPKLVTWMNNQRVGELTKLANGAHTFKYAPEWLANRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLLPENETITRPIMAWEQLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGNVRALAVERFDRRW
NAERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIARIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGAGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHGRLSREYGIK

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9975.33 Da        Isoelectric Point: 6.2156

>AT255135 WP_001327997.1 NZ_CP103479:2632671-2632937 [Escherichia coli]
MMSFQKIYSPTQLANAMKLVRQQNGWTQSGLAKKIGIKQATISNFENNPDNTTLTTFFKILQSLELSMTLCDTKNASPES
TEQQDLEW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB V0Z3Q2

Antitoxin

Source ID Structure

References