Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 1072155..1072809 Replicon chromosome
Accession NZ_CP103479
Organism Escherichia coli strain 4621

Toxin (Protein)


Gene name cptA Uniprot ID S1PAM6
Locus tag M5T46_RS05255 Protein ID WP_000244781.1
Coordinates 1072402..1072809 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag M5T46_RS05250 Protein ID WP_000354046.1
Coordinates 1072155..1072421 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T46_RS05230 (1068243) 1068243..1069676 - 1434 WP_001559758.1 6-phospho-beta-glucosidase BglA -
M5T46_RS05235 (1069721) 1069721..1070032 + 312 WP_001182957.1 N(4)-acetylcytidine aminohydrolase -
M5T46_RS05240 (1070196) 1070196..1070855 + 660 WP_000250269.1 hemolysin III family protein -
M5T46_RS05245 (1070932) 1070932..1071912 - 981 WP_000886086.1 tRNA-modifying protein YgfZ -
M5T46_RS05250 (1072155) 1072155..1072421 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
M5T46_RS05255 (1072402) 1072402..1072809 + 408 WP_000244781.1 protein YgfX Toxin
M5T46_RS05260 (1072849) 1072849..1073370 - 522 WP_001055874.1 flavodoxin FldB -
M5T46_RS05265 (1073482) 1073482..1074378 + 897 WP_000806652.1 site-specific tyrosine recombinase XerD -
M5T46_RS05270 (1074403) 1074403..1075113 + 711 WP_000715213.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
M5T46_RS05275 (1075119) 1075119..1076852 + 1734 WP_000813226.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 16061.99 Da        Isoelectric Point: 11.5202

>T255128 WP_000244781.1 NZ_CP103479:1072402-1072809 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDSGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT255128 WP_000354046.1 NZ_CP103479:1072155-1072421 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1PAM6

Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References