Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) PanAT/DUF4065(antitoxin)
Location 4730113..4731038 Replicon chromosome
Accession NZ_CP103468
Organism Escherichia coli strain 4973

Toxin (Protein)


Gene name panT Uniprot ID -
Locus tag M5S50_RS22985 Protein ID WP_014640052.1
Coordinates 4730113..4730499 (-) Length 129 a.a.

Antitoxin (Protein)


Gene name panA Uniprot ID -
Locus tag M5S50_RS22990 Protein ID WP_001339382.1
Coordinates 4730529..4731038 (-) Length 170 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S50_RS22935 (4725201) 4725201..4725446 - 246 WP_000141753.1 hypothetical protein -
M5S50_RS22940 (4725559) 4725559..4725869 + 311 Protein_4497 hypothetical protein -
M5S50_RS22945 (4725884) 4725884..4726246 + 363 WP_000135682.1 protein YfdP -
M5S50_RS22950 (4726312) 4726312..4727136 + 825 WP_089438609.1 DUF2303 family protein -
M5S50_RS22955 (4727264) 4727264..4727800 + 537 WP_000008200.1 5'-deoxynucleotidase -
M5S50_RS22960 (4727791) 4727791..4728153 + 363 WP_001565177.1 phage protein -
M5S50_RS22965 (4728153) 4728153..4728962 + 810 WP_000206745.1 hypothetical protein -
M5S50_RS22970 (4728962) 4728962..4729534 + 573 WP_001061348.1 3'-5' exonuclease -
M5S50_RS22975 (4729571) 4729571..4729852 + 282 WP_001093917.1 pyocin activator PrtN family protein -
M5S50_RS22980 (4729900) 4729900..4730073 - 174 WP_000390072.1 hypothetical protein -
M5S50_RS22985 (4730113) 4730113..4730499 - 387 WP_014640052.1 hypothetical protein Toxin
M5S50_RS22990 (4730529) 4730529..4731038 - 510 WP_001339382.1 Panacea domain-containing protein Antitoxin
M5S50_RS22995 (4731355) 4731355..4731459 - 105 Protein_4508 tRNA-dihydrouridine synthase -
M5S50_RS23000 (4731821) 4731821..4732825 - 1005 WP_022646425.1 DUF2713 family protein -
M5S50_RS23005 (4733143) 4733143..4733658 + 516 WP_000416263.1 zinc uptake transcriptional repressor Zur -
M5S50_RS23010 (4733700) 4733700..4733909 - 210 WP_001296638.1 CsbD family protein -
M5S50_RS23015 (4734025) 4734025..4735350 - 1326 WP_001361471.1 MATE family efflux transporter DinF -
M5S50_RS23020 (4735423) 4735423..4736031 - 609 WP_000646078.1 transcriptional repressor LexA -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 4689752..4736031 46279


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Antitoxin SocA-like, Panacea domain

(6-116)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14465.40 Da        Isoelectric Point: 5.4833

>T255116 WP_014640052.1 NZ_CP103468:c4730499-4730113 [Escherichia coli]
VLAPTGPCNHLHVICNDPVYYPVNDCYCVLVVNISSIKDGVPHDPSCVLNSGDHRFIKHPSYVVYAEAIIWRVDNMVRKQ
RSGEISVHDDMPEATFNRILDGFDISDEVTPKNLKFKNKYCVSSIDDE

Download         Length: 387 bp

Antitoxin


Download         Length: 170 a.a.        Molecular weight: 19576.29 Da        Isoelectric Point: 5.3338

>AT255116 WP_001339382.1 NZ_CP103468:c4731038-4730529 [Escherichia coli]
MAYLKLMKLLYLSNRQSILKHGRMIGEDSLYSMKFGPVMSNTLNLIRGKAEGIGDYWYNLIETNGHNVSLRSDPREMDAD
EVFDELSRADIRILDEIYSRYGHMNRFDLANMTHLESVCPEWHDPGNSRKPIDLKEMLISEGKSEDEANRIIGKMEESQK
LKEFSLQLS

Download         Length: 510 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References