Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3796706..3797324 Replicon chromosome
Accession NZ_CP103468
Organism Escherichia coli strain 4973

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5S50_RS18335 Protein ID WP_001291435.1
Coordinates 3797106..3797324 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5S50_RS18330 Protein ID WP_000344800.1
Coordinates 3796706..3797080 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S50_RS18320 (3791795) 3791795..3792988 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5S50_RS18325 (3793011) 3793011..3796160 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
M5S50_RS18330 (3796706) 3796706..3797080 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5S50_RS18335 (3797106) 3797106..3797324 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5S50_RS18340 (3797496) 3797496..3798047 + 552 WP_000102574.1 maltose O-acetyltransferase -
M5S50_RS18345 (3798163) 3798163..3798633 + 471 WP_022645280.1 YlaC family protein -
M5S50_RS18350 (3798797) 3798797..3800347 + 1551 WP_022645279.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5S50_RS18355 (3800389) 3800389..3800742 - 354 WP_000878140.1 DUF1428 domain-containing protein -
M5S50_RS18365 (3801121) 3801121..3801432 + 312 WP_000409911.1 MGMT family protein -
M5S50_RS18370 (3801463) 3801463..3802035 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255110 WP_001291435.1 NZ_CP103468:3797106-3797324 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255110 WP_000344800.1 NZ_CP103468:3796706-3797080 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References