Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH_XRE
Location 3356110..3356815 Replicon chromosome
Accession NZ_CP103468
Organism Escherichia coli strain 4973

Toxin (Protein)


Gene name relE Uniprot ID S1F406
Locus tag M5S50_RS16155 Protein ID WP_000539521.1
Coordinates 3356110..3356496 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag M5S50_RS16160 Protein ID WP_001280945.1
Coordinates 3356486..3356815 (+) Length 110 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S50_RS16135 (3352114) 3352114..3352740 + 627 WP_001295292.1 glutathione S-transferase GstB -
M5S50_RS16140 (3352737) 3352737..3353852 - 1116 WP_000554964.1 aldose sugar dehydrogenase YliI -
M5S50_RS16145 (3353963) 3353963..3354346 - 384 WP_000497137.1 biofilm formation regulator BssR -
M5S50_RS16150 (3354559) 3354559..3355884 + 1326 WP_000049367.1 30S ribosomal protein S12 methylthiotransferase RimO -
M5S50_RS16155 (3356110) 3356110..3356496 + 387 WP_000539521.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5S50_RS16160 (3356486) 3356486..3356815 + 330 WP_001280945.1 DNA-binding transcriptional regulator Antitoxin
M5S50_RS16165 (3356885) 3356885..3358213 - 1329 WP_022645414.1 GGDEF domain-containing protein -
M5S50_RS16170 (3358221) 3358221..3360569 - 2349 WP_022645413.1 EAL domain-containing protein -
M5S50_RS16175 (3360746) 3360746..3361657 - 912 WP_001236044.1 glutathione ABC transporter permease GsiD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(53-94)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14293.45 Da        Isoelectric Point: 9.9296

>T255108 WP_000539521.1 NZ_CP103468:3356110-3356496 [Escherichia coli]
MGVYKARRFSQSTKKLGIHDKVLMAAAEEVMQGIWEADLGSGVIKKRLPLQQGKSGGARTIIFFKSANHVFFYDGWSKSG
LSSKGTKEIEDDELAAYKKMANAFLAFSNKQIEDLIETGFLIEVKNER

Download         Length: 387 bp

Antitoxin


Download         Length: 110 a.a.        Molecular weight: 11982.08 Da        Isoelectric Point: 10.0101

>AT255108 WP_001280945.1 NZ_CP103468:3356486-3356815 [Escherichia coli]
MSDKLQMMLEDAKELNALGLMSDSEVDAIAVMVKAREVSARIAKVKSMTGEEIKAIRTRYGMSQSVLAHTMGMSKESVSK
WERNEIKPSGPALRILNTLAIKGPEVFAK

Download         Length: 330 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829GCT6

Antitoxin

Source ID Structure

References