Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/UPF0150(antitoxin)
Location 2664579..2665217 Replicon chromosome
Accession NZ_CP103468
Organism Escherichia coli strain 4973

Toxin (Protein)


Gene name hicA Uniprot ID S1F9G9
Locus tag M5S50_RS12710 Protein ID WP_000813794.1
Coordinates 2665041..2665217 (-) Length 59 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag M5S50_RS12705 Protein ID WP_001270286.1
Coordinates 2664579..2664995 (-) Length 139 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5S50_RS12685 (2659731) 2659731..2660672 - 942 WP_022645667.1 ABC transporter permease -
M5S50_RS12690 (2660673) 2660673..2661686 - 1014 WP_022645666.1 ABC transporter ATP-binding protein -
M5S50_RS12695 (2661704) 2661704..2662849 - 1146 WP_000047466.1 ABC transporter substrate-binding protein -
M5S50_RS12700 (2663094) 2663094..2664500 - 1407 WP_022645665.1 PLP-dependent aminotransferase family protein -
M5S50_RS12705 (2664579) 2664579..2664995 - 417 WP_001270286.1 type II toxin-antitoxin system antitoxin HicB Antitoxin
M5S50_RS12710 (2665041) 2665041..2665217 - 177 WP_000813794.1 type II toxin-antitoxin system mRNA interferase toxin HicA Toxin
M5S50_RS12715 (2665439) 2665439..2665669 + 231 WP_000491567.1 DUF2554 family protein -
M5S50_RS12720 (2665761) 2665761..2667722 - 1962 WP_023909195.1 23S rRNA 5-hydroxycytidine C2501 synthase -
M5S50_RS12725 (2667795) 2667795..2668331 - 537 WP_000429148.1 DNA-binding transcriptional regulator SutR -
M5S50_RS12730 (2668423) 2668423..2669595 + 1173 WP_022645663.1 BenE family transporter YdcO -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-57)

Antitoxin

Cro/C1-type helix-turn-helix domain

(91-134)


Sequences

Toxin        


Download         Length: 59 a.a.        Molecular weight: 6749.83 Da        Isoelectric Point: 11.2298

>T255106 WP_000813794.1 NZ_CP103468:c2665217-2665041 [Escherichia coli]
VKQSEFRRWLESQGVDVANGSNHLKLRFHGRRSVMPRHPCDEIKEPLRKAILKQLGLS

Download         Length: 177 bp

Antitoxin


Download         Length: 139 a.a.        Molecular weight: 15246.63 Da        Isoelectric Point: 4.7386

>AT255106 WP_001270286.1 NZ_CP103468:c2664995-2664579 [Escherichia coli]
MRYPVTLTPAPEGGYMVSFVDIPEALTQGETVAEAMEAAKDALLTAFDFYFEDNELIPLPSPLNSHDHFIEVPLSVASKV
LLLNAFLQSEITQQELARRIGKPKQEITRLFNLHHATKIDAVQLAAKALGKELSLVMV

Download         Length: 417 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 6HPB

Antitoxin

Source ID Structure

References