Detailed information of TA system TA025509

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): pezAT/zeta-ParD
• Location: 452038..453049
• Replicon: chromosome
• Accession: NC_015848
• Organism: Mycobacterium canettii CIPT 140010059

Toxin (Protein)

• Gene name: pezT
• Uniprot ID: G0TNV2
• Locus tag: MCAN_RS01915
• Protein ID: WP_014000190.1
• Coordinates: 452038..452631 (-)
• Length: 198 a.a.

Antitoxin (Protein)

• Gene name: pezA
• Uniprot ID: G0TNV3
• Locus tag: MCAN_RS01920
• Protein ID: WP_014000191.1
• Coordinates: 452660..453049 (-)
• Length: 130 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCAN_RS01895	447687..449069	+	1383	WP_003898415.1	magnesium transporter	-
MCAN_RS01900	449081..450115	-	1035	WP_003401856.1	class II fructose-bisphosphate aldolase	-
MCAN_RS01905	450211..450894	+	684	WP_003401857.1	VTT domain-containing protein	-
MCAN_RS01910	450883..452013	-	1131	WP_003401858.1	hypothetical protein	-
MCAN_RS01915	452038..452631	-	594	WP_014000190.1	zeta toxin family protein	Toxin
MCAN_RS01920	452660..453049	-	390	WP_014000191.1	hypothetical protein	Antitoxin
MCAN_RS01925	453130..454341	-	1212	WP_014000192.1	VWA domain-containing protein	-
MCAN_RS01930	454347..454949	-	603	WP_041179818.1	SRPBCC family protein	-
MCAN_RS01935	454963..455859	-	897	WP_014000193.1	MoxR family ATPase	-
MCAN_RS01940	455856..456449	-	594	WP_014000194.1	NTP transferase domain-containing protein	-
MCAN_RS01945	456446..457201	-	756	WP_003401865.1	XdhC family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Zeta toxin domain (4-156)

Antitoxin

• ParD-like antitoxin of type II bacterial toxin-antitoxin system (6-106)

Sequences

Toxin

Protein

• Length: 198 a.a.
• Molecular weight: 21403.51 Da
• Isoelectric Point: 10.2647

>T25509 WP_014000190.1 NC_015848:c452631-452038 [Mycobacterium canettii CIPT 140010059]
VKRLDLVAGPNGAGKSTFVALTLAPLLPGIVFVNADEIAKQRWPDDPTSHAYQAAQVAADTRARLIDLGRPFIAETVFSH
PSKLELIRTARTAGYTVVLHVLVIPEDLAVERVRHRVAAGGHDVPETKIRERHRRLAELVAQAITLADGATVYDNSRLAG
PRNVAQFSGGGIIGRACWPSWTPPPLMSRWSNRPETA

Nucleotide

• Length: 594 bp

>T25509 NC_015848:c452631-452038 [Mycobacterium canettii CIPT 140010059]
GTGAAGCGGCTCGATCTGGTCGCCGGGCCCAACGGCGCCGGCAAGTCGACGTTCGTCGCCCTCACGCTGGCGCCCTTGCT
GCCCGGCATCGTCTTCGTCAACGCCGACGAAATCGCCAAACAACGCTGGCCCGACGACCCAACATCGCACGCCTACCAGG
CGGCGCAGGTCGCCGCCGACACCCGCGCGAGGCTCATCGACTTGGGCCGGCCGTTCATTGCCGAGACGGTGTTCTCGCAC
CCATCGAAGCTCGAGCTCATCCGCACCGCGCGCACGGCCGGCTACACCGTCGTACTGCACGTGTTGGTTATCCCCGAAGA
CCTGGCGGTCGAGCGCGTCAGGCATCGCGTCGCCGCGGGCGGCCACGATGTGCCGGAGACCAAGATCCGCGAGCGTCACC
GCCGGCTGGCCGAGCTTGTCGCCCAGGCCATCACGCTGGCCGACGGCGCCACCGTCTATGACAACAGCCGGCTCGCGGGC
CCGCGGAACGTCGCTCAGTTCAGCGGGGGTGGCATCATCGGGCGCGCATGCTGGCCTTCGTGGACGCCGCCACCCTTGAT
GTCACGCTGGAGTAACAGGCCTGAGACGGCGTAA

Antitoxin

Protein

• Length: 130 a.a.
• Molecular weight: 13735.36 Da
• Isoelectric Point: 6.4864

>AT25509 WP_014000191.1 NC_015848:c453049-452660 [Mycobacterium canettii CIPT 140010059]
MPKAVDRVTRVAADLVDSAAAEGARQSRSAKQQLDHWARVGRAVSNQHTASRRRVEAALAGHLPMRDLTLEEGVVFNAEI
SAAIEERLSRTNYGDVLAAQGITTVALNDAGDIVEHRPDGTSVVLAATP

Nucleotide

• Length: 390 bp

>AT25509 NC_015848:c453049-452660 [Mycobacterium canettii CIPT 140010059]
ATGCCCAAAGCCGTCGACCGCGTCACGCGCGTCGCCGCGGATCTGGTGGACAGCGCGGCGGCCGAGGGTGCTCGTCAGAG
CCGTTCGGCCAAGCAGCAGCTCGACCACTGGGCCCGCGTCGGTCGGGCGGTGTCGAACCAGCACACGGCGTCGCGGCGCC
GCGTGGAAGCTGCGCTCGCGGGGCATCTGCCGATGAGGGACCTGACGCTGGAGGAGGGCGTGGTGTTCAACGCCGAGATC
TCCGCAGCTATCGAGGAGCGCCTGTCGCGAACCAACTACGGCGACGTGCTCGCCGCGCAGGGCATCACCACGGTCGCCCT
GAACGACGCGGGCGACATCGTCGAGCACCGGCCAGACGGCACCTCGGTCGTGCTGGCGGCCACGCCGTGA

Structures

Toxin

• AlphaFold DB: G0TNV2

Antitoxin

• AlphaFold DB: G0TNV3