255086

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3502785..3503403 Replicon chromosome
Accession NZ_CP103465
Organism Escherichia coli O25b:H4-ST131 strain 5392

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag M5T42_RS17020 Protein ID WP_001291435.1
Coordinates 3503185..3503403 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag M5T42_RS17015 Protein ID WP_000344800.1
Coordinates 3502785..3503159 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T42_RS17005 (3497874) 3497874..3499067 + 1194 WP_001295833.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
M5T42_RS17010 (3499090) 3499090..3502239 + 3150 WP_001132478.1 efflux RND transporter permease AcrB -
M5T42_RS17015 (3502785) 3502785..3503159 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
M5T42_RS17020 (3503185) 3503185..3503403 + 219 WP_001291435.1 HHA domain-containing protein Toxin
M5T42_RS17025 (3503576) 3503576..3504127 + 552 WP_000102539.1 maltose O-acetyltransferase -
M5T42_RS17030 (3504243) 3504243..3504713 + 471 WP_000136192.1 YlaC family protein -
M5T42_RS17035 (3504877) 3504877..3506427 + 1551 WP_001545832.1 cyclic-guanylate-specific phosphodiesterase PdeB -
M5T42_RS17040 (3506469) 3506469..3506822 - 354 WP_000878147.1 DUF1428 family protein -
M5T42_RS17050 (3507201) 3507201..3507512 + 312 WP_000409908.1 MGMT family protein -
M5T42_RS17055 (3507543) 3507543..3508115 - 573 WP_000779841.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T255086 WP_001291435.1 NZ_CP103465:3503185-3503403 [Escherichia coli O25b:H4-ST131]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT255086 WP_000344800.1 NZ_CP103465:3502785-3503159 [Escherichia coli O25b:H4-ST131]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References