255084

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) paaR-paaA-parE/-
Location 2833389..2833860 Replicon chromosome
Accession NZ_CP103465
Organism Escherichia coli O25b:H4-ST131 strain 5392

Toxin (Protein)


Gene name parE_1 Uniprot ID A0A0D7C2L1
Locus tag M5T42_RS13770 Protein ID WP_001303511.1
Coordinates 2833582..2833860 (+) Length 93 a.a.

Antitoxin (Protein)


Gene name paaA Uniprot ID Q8XAD5
Locus tag M5T42_RS13765 Protein ID WP_001302048.1
Coordinates 2833389..2833580 (+) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
M5T42_RS13720 (2828638) 2828638..2828856 - 219 WP_001610644.1 DUF4014 family protein -
M5T42_RS13725 (2828889) 2828889..2829101 - 213 WP_000072553.1 hypothetical protein -
M5T42_RS13730 (2829207) 2829207..2829629 - 423 Protein_2695 DUF977 family protein -
M5T42_RS13735 (2829645) 2829645..2830415 - 771 WP_000450998.1 DUF1627 domain-containing protein -
M5T42_RS13740 (2830437) 2830437..2831183 - 747 WP_000788950.1 ATP-binding protein -
M5T42_RS13745 (2831190) 2831190..2832152 - 963 WP_000095673.1 helix-turn-helix domain-containing protein -
M5T42_RS13750 (2832175) 2832175..2832600 - 426 WP_000693943.1 toxin YdaT family protein -
M5T42_RS13755 (2832597) 2832597..2832899 - 303 WP_001556930.1 transcriptional regulator -
M5T42_RS13760 (2832997) 2832997..2833368 + 372 WP_001169687.1 hypothetical protein -
M5T42_RS13765 (2833389) 2833389..2833580 + 192 WP_001302048.1 hypothetical protein Antitoxin
M5T42_RS13770 (2833582) 2833582..2833860 + 279 WP_001303511.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
M5T42_RS13775 (2834151) 2834151..2834303 + 153 WP_000380313.1 DUF1391 family protein -
M5T42_RS13780 (2834315) 2834315..2834653 + 339 WP_000394541.1 hypothetical protein -
M5T42_RS13785 (2834642) 2834642..2834836 - 195 WP_001295058.1 hypothetical protein -
M5T42_RS13790 (2835412) 2835412..2835600 + 189 WP_000449175.1 cell division inhibition protein DicB -
M5T42_RS13795 (2835597) 2835597..2835785 + 189 WP_000199475.1 DUF1482 family protein -
M5T42_RS13800 (2835878) 2835878..2838316 + 2439 WP_000102132.1 exonuclease -
M5T42_RS13805 (2838378) 2838378..2838647 + 270 WP_000003742.1 excisionase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 2786900..2846902 60002


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-91)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 93 a.a.        Molecular weight: 10661.25 Da        Isoelectric Point: 5.5647

>T255084 WP_001303511.1 NZ_CP103465:2833582-2833860 [Escherichia coli O25b:H4-ST131]
MLPVLWLESADTDLDDITSYIARFDIDAAERLWQRLRGCVLPLSEHPYLYPPSDRVPGLREIVAHPNYIILYRVTTSSVE
VVNVIHARRQFP

Download         Length: 279 bp

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7463.47 Da        Isoelectric Point: 8.6828

>AT255084 WP_001302048.1 NZ_CP103465:2833389-2833580 [Escherichia coli O25b:H4-ST131]
MNRALSPMVSEFETIEQENSYNEWLRAKVATSLADPRPAIPHDEVERRMAERFAKMRKERSKQ

Download         Length: 192 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 5CZF
PDB 5CW7
PDB 5CZE

Antitoxin

Source ID Structure
PDB 5CZF
PDB 3ZBE
PDB 5CW7
AlphaFold DB A0A829CTP0

References