Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hipBA/HipA-HipB |
Location | 2439770..2441358 | Replicon | chromosome |
Accession | NZ_CP103465 | ||
Organism | Escherichia coli O25b:H4-ST131 strain 5392 |
Toxin (Protein)
Gene name | hipA | Uniprot ID | A0A061YM43 |
Locus tag | M5T42_RS11760 | Protein ID | WP_001125411.1 |
Coordinates | 2440036..2441358 (+) | Length | 441 a.a. |
Antitoxin (Protein)
Gene name | hipB | Uniprot ID | A0A061YNW4 |
Locus tag | M5T42_RS11755 | Protein ID | WP_001296076.1 |
Coordinates | 2439770..2440036 (+) | Length | 89 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M5T42_RS11740 (2436138) | 2436138..2437589 | + | 1452 | WP_000854638.1 | tagaturonate reductase | - |
M5T42_RS11745 (2437786) | 2437786..2438700 | + | 915 | WP_001296077.1 | bestrophin family protein | - |
M5T42_RS11750 (2438704) | 2438704..2439462 | - | 759 | WP_001286537.1 | trans-aconitate 2-methyltransferase | - |
M5T42_RS11755 (2439770) | 2439770..2440036 | + | 267 | WP_001296076.1 | type II toxin-antitoxin system antitoxin HipB | Antitoxin |
M5T42_RS11760 (2440036) | 2440036..2441358 | + | 1323 | WP_001125411.1 | type II toxin-antitoxin system serine/threonine protein kinase toxin HipA | Toxin |
M5T42_RS11765 (2442268) | 2442268..2442831 | + | 564 | WP_001296074.1 | type 1 fimbrial major subunit FimA | - |
M5T42_RS11770 (2443193) | 2443193..2443903 | + | 711 | WP_001195177.1 | fimbria/pilus periplasmic chaperone | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 441 a.a. Molecular weight: 49329.96 Da Isoelectric Point: 7.7906
>T255083 WP_001125411.1 NZ_CP103465:2440036-2441358 [Escherichia coli O25b:H4-ST131]
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK
MPKLVTWMNNQRVGELTKLANGAHTFKYAAEWLASRYARPLSLSLPLQRGNITSDAVFNFFDNLLPDSPIVRDRIVKRYH
AKSRQPFDLLSEIGRDSVGAVTLIPEDETVTCPIMAWEKLTEARLEEVLTAYKADIPLGMIREENDFRISVAGAQEKTAL
LRIGNDWCIPKGITPTTHIIKLPIGEIRQPNATLDLSQSVDNEYYCLLLAKELGLNVPDAEIIKAGRVRALAVERFDRRW
NTERTVLLRLPQEDMCQTFGLPSSVKYESDGGPGIAQIMAFLMGSSEALKDRYDFMKFQVFQWLIGATDGHAKNFSVFIQ
AGGSYRLTPFYDIISAFPVLGGTGIHISDLKLAMGLNASKGKKTAIDKIYPRHFLATAKVLKFPEVQMHEILSDFARMIP
AALDNVKTSLPTDFPENVVTAVETNVLRLHDRLSREYGIK
Download Length: 1323 bp
Antitoxin
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061YM43 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A061YNW4 |