Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | sanaTA/AbiEii-DUF6088 |
Location | 801931..803212 | Replicon | chromosome |
Accession | NZ_CP103465 | ||
Organism | Escherichia coli O25b:H4-ST131 strain 5392 |
Toxin (Protein)
Gene name | sanaT | Uniprot ID | A0A1X3JHM4 |
Locus tag | M5T42_RS03900 | Protein ID | WP_001114681.1 |
Coordinates | 801931..802824 (-) | Length | 298 a.a. |
Antitoxin (Protein)
Gene name | sanaA | Uniprot ID | V0YCI1 |
Locus tag | M5T42_RS03905 | Protein ID | WP_000208383.1 |
Coordinates | 802817..803212 (-) | Length | 132 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
M5T42_RS03885 (798280) | 798280..799428 | - | 1149 | WP_000905920.1 | capsule polysaccharide export inner-membrane protein KpsE | - |
M5T42_RS03890 (799500) | 799500..800483 | - | 984 | WP_001298261.1 | KpsF/GutQ family sugar-phosphate isomerase | - |
M5T42_RS03895 (801290) | 801290..801460 | - | 171 | Protein_765 | IS110 family transposase | - |
M5T42_RS03900 (801931) | 801931..802824 | - | 894 | WP_001114681.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
M5T42_RS03905 (802817) | 802817..803212 | - | 396 | WP_000208383.1 | DUF6088 family protein | Antitoxin |
M5T42_RS03910 (803281) | 803281..804126 | - | 846 | WP_001529401.1 | DUF4942 domain-containing protein | - |
M5T42_RS03915 (804211) | 804211..804408 | - | 198 | WP_000839293.1 | DUF957 domain-containing protein | - |
M5T42_RS03920 (804425) | 804425..804913 | - | 489 | WP_000761699.1 | DUF5983 family protein | - |
M5T42_RS03925 (804910) | 804910..805287 | - | 378 | WP_000854690.1 | TA system toxin CbtA family protein | - |
M5T42_RS03930 (805376) | 805376..805744 | - | 369 | WP_001305076.1 | type IV toxin-antitoxin system YeeU family antitoxin | - |
M5T42_RS03935 (805794) | 805794..806438 | - | 645 | WP_000094916.1 | hypothetical protein | - |
M5T42_RS03940 (806457) | 806457..806678 | - | 222 | WP_000692329.1 | DUF987 domain-containing protein | - |
M5T42_RS03945 (806741) | 806741..807217 | - | 477 | WP_001186726.1 | RadC family protein | - |
M5T42_RS03950 (807233) | 807233..807718 | - | 486 | WP_000849565.1 | antirestriction protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|---|---|---|---|---|---|---|
- | inside | Genomic island | - | kpsM / kpsT / kpsS / kpsC / kpsU / kpsD / kpsE / kpsF / sat | 785830..853956 | 68126 | |
- | flank | IS/Tn | - | - | 801290..801445 | 155 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 298 a.a. Molecular weight: 34298.40 Da Isoelectric Point: 5.9850
>T255074 WP_001114681.1 NZ_CP103465:c802824-801931 [Escherichia coli O25b:H4-ST131]
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
MPELTSLFPDVADALDIESVAIVEKDYFVVDLLRLLKEIKPETHTLVFAGSTALSKAGISLNRMSEDIDIKLVPTENFMQ
NGRDKRRKIRKEIVQIITDVIHNSDIFSLDNENARITRDEYRYNEISVRYPQTFAQVPCLRPFIKLELMESTLLEHPESR
DIYSLVTELTGKGTPITAFPCATILSTQAEKLISMMRRTAAHLRNPEQQDDEFLVRHIYDNYCIVREKGVNVPVLKNFVQ
ICIQQDIERYGNQYPQFCSSPVDELKKGLDALRDYPVHKLRFQRFVNPMVFGNTQIN
Download Length: 894 bp
Antitoxin
Download Length: 132 a.a. Molecular weight: 14608.03 Da Isoelectric Point: 11.3150
>AT255074 WP_000208383.1 NZ_CP103465:c803212-802817 [Escherichia coli O25b:H4-ST131]
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
MTTKDRIQSRLNRSKRYVFTRDDFRDIAGYDQVGRALRTLVNEGKLMKVGYGVYTKARRNIITGKIMPAAPGGSAAVITE
ALERLNIRYRLAGATECYNKGQSTQIPVSLGIKTPSRFKRVLIVGKSKINA
Download Length: 396 bp
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A1X3JHM4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | V0YCI1 |