Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 2373536..2374052 Replicon chromosome
Accession NZ_CP103450
Organism Erwinia pyrifoliae strain CP201179

Toxin (Protein)


Gene name relE Uniprot ID D2T7S6
Locus tag NYP81_RS11365 Protein ID WP_012669379.1
Coordinates 2373536..2373820 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2T7S5
Locus tag NYP81_RS11370 Protein ID WP_012669378.1
Coordinates 2373810..2374052 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP81_RS11340 (NYP81_11340) 2370025..2370294 + 270 WP_259820067.1 type I toxin-antitoxin system SymE family toxin -
NYP81_RS11345 (NYP81_11345) 2370355..2370786 - 432 WP_012667206.1 hypothetical protein -
NYP81_RS11350 (NYP81_11350) 2370788..2371045 - 258 WP_259820069.1 HNH/ENDO VII family nuclease -
NYP81_RS11355 (NYP81_11355) 2371317..2371577 - 261 WP_259818784.1 hypothetical protein -
NYP81_RS11360 (NYP81_11360) 2371780..2372915 + 1136 WP_104945024.1 IS3 family transposase -
NYP81_RS11365 (NYP81_11365) 2373536..2373820 - 285 WP_012669379.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYP81_RS11370 (NYP81_11370) 2373810..2374052 - 243 WP_012669378.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
NYP81_RS11375 (NYP81_11375) 2374313..2375368 - 1056 WP_259818775.1 site-specific tyrosine recombinase XerC -
NYP81_RS11380 (NYP81_11380) 2375567..2378260 - 2694 WP_259818825.1 CHC2 zinc finger domain-containing protein -
NYP81_RS11385 (NYP81_11385) 2378358..2378756 + 399 WP_259818826.1 helix-turn-helix transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-82)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-64)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 11123.03 Da        Isoelectric Point: 10.3769

>T255064 WP_012669379.1 NZ_CP103450:c2373820-2373536 [Erwinia pyrifoliae]
MSYELVFDPRALKEWKKLGATVREQFKKKLAEVLVNPRVESARLREYPDCYKIKLKSSGYRLVYQVQDEQLVVFVVATGK
RERLQVYRDAGKRL

Download         Length: 285 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 9070.45 Da        Isoelectric Point: 4.6310

>AT255064 WP_012669378.1 NZ_CP103450:c2374052-2373810 [Erwinia pyrifoliae]
MATLNVRLDDKLKSKAYAVLDELDVSPTEAVRLLFQYIAENERLPLKTLTVSDEEDALLKTVRERLASPQKGIRVTLDEL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2T7S6

Antitoxin

Source ID Structure
AlphaFold DB D2T7S5

References