Detailed information of TA system TA255061

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 1588945..1590628
• Replicon: chromosome
• Accession: NZ_CP103450
• Organism: Erwinia pyrifoliae strain CP201179

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: NYP81_RS07785
• Protein ID: WP_259819842.1
• Coordinates: 1588945..1589862 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: D2T9Q4
• Locus tag: NYP81_RS07790
• Protein ID: WP_012667836.1
• Coordinates: 1589855..1590628 (-)
• Length: 258 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NYP81_RS07765 (NYP81_07765)	1584755..1585564	-	810	WP_259819840.1	trehalose-phosphatase	-
NYP81_RS07770 (NYP81_07770)	1586279..1587010	+	732	WP_012667840.1	YoaK family protein	-
NYP81_RS07775 (NYP81_07775)	1587182..1587601	+	420	WP_012667839.1	translesion error-prone DNA polymerase V autoproteolytic subunit	-
NYP81_RS07780 (NYP81_07780)	1587604..1588866	+	1263	WP_012667838.1	translesion error-prone DNA polymerase V subunit UmuC	-
NYP81_RS07785 (NYP81_07785)	1588945..1589862	-	918	WP_259819842.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NYP81_RS07790 (NYP81_07790)	1589855..1590628	-	774	WP_012667836.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NYP81_RS07795 (NYP81_07795)	1590691..1590828	+	138	Protein_1504	IS3 family transposase	-
NYP81_RS07800 (NYP81_07800)	1591113..1592090	-	978	WP_012667835.1	porphobilinogen synthase	-
NYP81_RS07805 (NYP81_07805)	1592330..1592896	+	567	WP_041473991.1	NADPH-dependent FMN reductase	-
NYP81_RS07810 (NYP81_07810)	1592991..1594325	+	1335	WP_012667833.1	cation:proton antiporter	-
NYP81_RS07815 (NYP81_07815)	1594582..1594944	-	363	WP_014538840.1	PTS galactitol transporter subunit IIA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34260.44 Da
• Isoelectric Point: 4.7488

>T255061 WP_259819842.1 NZ_CP103450:c1589862-1588945 [Erwinia pyrifoliae]
MDKQSPYYQQVALLLSALPVVAAERCFALKGGTAINLFVRDFPRLSVDIDLAYVLLESRDVALPNVRAALMRIAEILQQQ
AGISAVLQTNHSDEMRIVVSSQEAQIKIEVSPVARGTLYPPEERDIVEAVEDEFGFATIQVVSLADLYGGKLCAALDRQH
PRDFYDVKMLLETQGIDRQIFNGFITYLLGHQRPLSEVLNPRWKDISELYANEFNGMTFDAVSLEELNAIPNLMVTALKA
QFTQQDYDFLMSFKSGQPDWSLAPEDQIQHLPAVKWKLQNIGCIPKGKHIQALAKLEAVLAEWIK

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 258 a.a.
• Molecular weight: 28877.26 Da
• Isoelectric Point: 10.0532

>AT255061 WP_012667836.1 NZ_CP103450:c1590628-1589855 [Erwinia pyrifoliae]
MSSKLNWLLQNTAPGSLVLQSWLTKNGISPSLANKYMHSDWLQKLRAGVYVRSGREPQWNDAVLCLQNQLGISVHLAGLT
SLTWQGRSHYLHLTRQAIWLYVEDKASLPKWFKEFPNVEWLLLSNQKLNMNDEKYLTAVEIKGERLKASVPELAAYEIAN
AVPGSLSFEHAAELFQGLVNLSPRKVEVLLQSSRAVKTNRLYLFLADHYAHAWVTRIDKANIDLGAGKRQIVSGGKLDLK
YQITVPASFVSKGISHG

Nucleotide

• Length: 774 bp

Structures

Antitoxin

• AlphaFold DB: D2T9Q4