Detailed information of TA system TA025506

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-RHH
• Location: 4614786..4615327
• Replicon: chromosome
• Accession: NC_015844
• Organism: Zobellia galactanivorans

Toxin (Protein)

• Gene name: parE
• Uniprot ID: G0L2D3
• Locus tag: ZOBGAL_RS18460
• Protein ID: WP_013995250.1
• Coordinates: 4615025..4615327 (+)
• Length: 101 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: G0L898
• Locus tag: ZOBGAL_RS18455
• Protein ID: WP_013995249.1
• Coordinates: 4614786..4615028 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ZOBGAL_RS18430	4609974..4610285	+	312	WP_046287590.1	DUF1778 domain-containing protein	-
ZOBGAL_RS18435	4610248..4610751	+	504	WP_013995244.1	GNAT family N-acetyltransferase	-
ZOBGAL_RS18440	4610816..4611367	+	552	WP_013995245.1	hypothetical protein	-
ZOBGAL_RS18445	4611702..4613675	+	1974	WP_013995247.1	hypothetical protein	-
ZOBGAL_RS18450	4613680..4614300	+	621	WP_013995248.1	hypothetical protein	-
ZOBGAL_RS18455	4614786..4615028	+	243	WP_013995249.1	type II toxin-antitoxin system ParD family antitoxin	Antitoxin
ZOBGAL_RS18460	4615025..4615327	+	303	WP_013995250.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
ZOBGAL_RS22910	4615952..4616548	+	597	WP_158499750.1	WG repeat-containing protein	-
ZOBGAL_RS18470	4616651..4617121	+	471	WP_013995253.1	OsmC family protein	-
ZOBGAL_RS18475	4617628..4618122	+	495	WP_046288073.1	hypothetical protein	-
ZOBGAL_RS18480	4618186..4619019	+	834	WP_013995257.1	DKNYY domain-containing protein	-
ZOBGAL_RS18485	4619219..4619548	+	330	WP_013995258.1	hypothetical protein	-
ZOBGAL_RS18490	4619567..4619920	+	354	WP_013995259.1	TerB family tellurite resistance protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (6-94)

Antitoxin

• Antitoxin ParD (1-79)

Sequences

Toxin

Protein

• Length: 101 a.a.
• Molecular weight: 12168.12 Da
• Isoelectric Point: 10.3185

>T25506 WP_013995250.1 NC_015844:4615025-4615327 [Zobellia galactanivorans]
MSKNKYRISKQAINDLNDIWVYTFNKWSKEQADRCYDLIIGEIEFIADNYQIGKSAEQTRKNYRVTKIKSHLIFYRKAEN
EIVEVLRILHQRMQIKKRLK

Nucleotide

• Length: 303 bp

>T25506 NC_015844:4615025-4615327 [Zobellia galactanivorans]
ATGAGTAAAAACAAATATCGAATCAGTAAACAAGCGATTAATGATTTAAATGATATTTGGGTCTATACTTTTAATAAATG
GTCTAAAGAACAAGCGGATAGATGTTACGACTTAATAATAGGGGAAATTGAATTTATTGCGGACAACTATCAAATTGGCA
AATCCGCTGAACAAACTCGAAAAAACTATCGAGTAACGAAAATCAAATCGCATCTTATTTTTTACAGAAAAGCCGAAAAT
GAAATTGTTGAAGTCCTTAGAATTCTACATCAGCGAATGCAAATAAAAAAACGACTGAAATAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 9242.26 Da
• Isoelectric Point: 5.6036

>AT25506 WP_013995249.1 NC_015844:4614786-4615028 [Zobellia galactanivorans]
MGKNTSISLGNHFEDFIREEVNSGRYSSVSEVIRSALRLLEHEEKKERELIKALEVGENSGFVEDFDPKQNLTELHRKHS

Nucleotide

• Length: 243 bp

>AT25506 NC_015844:4614786-4615028 [Zobellia galactanivorans]
ATGGGAAAAAACACCTCAATATCACTCGGAAATCATTTTGAAGATTTTATCAGAGAAGAAGTAAATTCGGGTAGGTACAG
TTCGGTTAGCGAAGTAATTCGTTCAGCGCTACGTTTGCTAGAACATGAAGAAAAAAAGGAAAGAGAACTGATTAAAGCCC
TCGAAGTTGGAGAAAATAGCGGATTTGTGGAAGATTTTGACCCAAAACAAAACCTGACTGAATTACATCGCAAACACTCA
TGA

Structures

Toxin

• AlphaFold DB: G0L2D3

Antitoxin

• AlphaFold DB: G0L898