Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 390295..390923 Replicon chromosome
Accession NZ_CP103450
Organism Erwinia pyrifoliae strain CP201179

Toxin (Protein)


Gene name Hha Uniprot ID D2T444
Locus tag NYP81_RS01840 Protein ID WP_004156337.1
Coordinates 390295..390513 (-) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID -
Locus tag NYP81_RS01845 Protein ID WP_012668861.1
Coordinates 390543..390923 (-) Length 127 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP81_RS01810 (NYP81_01810) 386278..386616 + 339 WP_012668866.1 P-II family nitrogen regulator -
NYP81_RS01815 (NYP81_01815) 386639..387940 + 1302 WP_259817862.1 ammonium transporter AmtB -
NYP81_RS01820 (NYP81_01820) 388015..388875 - 861 WP_259817863.1 acyl-CoA thioesterase II -
NYP81_RS01825 (NYP81_01825) 389099..389656 + 558 WP_012668863.1 YbaY family lipoprotein -
NYP81_RS01830 (NYP81_01830) 389679..389996 - 318 WP_012668862.1 MGMT family protein -
NYP81_RS01840 (NYP81_01840) 390295..390513 - 219 WP_004156337.1 HHA domain-containing protein Toxin
NYP81_RS01845 (NYP81_01845) 390543..390923 - 381 WP_012668861.1 Hha toxicity modulator TomB Antitoxin
NYP81_RS01850 (NYP81_01850) 391070..391423 - 354 WP_012668860.1 hypothetical protein -
NYP81_RS01855 (NYP81_01855) 391880..392026 - 147 WP_259818164.1 type B 50S ribosomal protein L36 -
NYP81_RS01860 (NYP81_01860) 392037..392297 - 261 WP_012668858.1 type B 50S ribosomal protein L31 -
NYP81_RS01865 (NYP81_01865) 392451..395591 - 3141 WP_012668857.1 multidrug efflux RND transporter permease subunit AcrB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8627.06 Da        Isoelectric Point: 8.9007

>T255059 WP_004156337.1 NZ_CP103450:c390513-390295 [Erwinia pyrifoliae]
MTDKLLTKTDYLMRLRRCRSIDTLERVIEKNKYELSDDELAVFYSAADHRLAELTMNKLYDKVPVAVWKFVR

Download         Length: 219 bp

Antitoxin


Download         Length: 127 a.a.        Molecular weight: 14721.47 Da        Isoelectric Point: 4.8834

>AT255059 WP_012668861.1 NZ_CP103450:c390923-390543 [Erwinia pyrifoliae]
MDEYSPKRHDIAQLKFLCENLYDESLATLGDSHHGWVNDPTSTSNLQLNDLIEHIAAFTMNYKIKHIEDCDLISQIDEYL
DDTFMLFSNYGVNTHDLQRWQKSAKRLFNIFAKECLMSQVQSSHSF

Download         Length: 381 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A831EPQ0

Antitoxin

Source ID Structure

References