Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 263087..263621 Replicon chromosome
Accession NZ_CP103450
Organism Erwinia pyrifoliae strain CP201179

Toxin (Protein)


Gene name relE Uniprot ID D2T5B9
Locus tag NYP81_RS01200 Protein ID WP_012668982.1
Coordinates 263334..263621 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID D2T5C0
Locus tag NYP81_RS01195 Protein ID WP_012668983.1
Coordinates 263087..263329 (+) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYP81_RS01170 (NYP81_01170) 258576..259070 + 495 WP_259819339.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NYP81_RS01175 (NYP81_01175) 259067..259402 + 336 WP_259819340.1 hydroxyisourate hydrolase -
NYP81_RS01180 (NYP81_01180) 259435..260760 + 1326 WP_259819341.1 nucleobase:cation symporter-2 family protein -
NYP81_RS01185 (NYP81_01185) 260744..261517 - 774 WP_259817818.1 amidohydrolase -
NYP81_RS01190 (NYP81_01190) 261505..262665 - 1161 WP_259819342.1 pyridoxal phosphate-dependent aminotransferase -
NYP81_RS01195 (NYP81_01195) 263087..263329 + 243 WP_012668983.1 plasmid stabilization protein Antitoxin
NYP81_RS01200 (NYP81_01200) 263334..263621 + 288 WP_012668982.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NYP81_RS01205 (NYP81_01205) 264068..264682 + 615 WP_259819343.1 methylthioribulose 1-phosphate dehydratase -
NYP81_RS01210 (NYP81_01210) 264679..265368 + 690 WP_259819344.1 acireductone synthase -
NYP81_RS01215 (NYP81_01215) 265365..265907 + 543 WP_259819345.1 acireductone dioxygenase -
NYP81_RS01220 (NYP81_01220) 265959..266990 - 1032 WP_259819347.1 S-methyl-5-thioribose-1-phosphate isomerase -
NYP81_RS01225 (NYP81_01225) 267105..268304 + 1200 WP_259819348.1 S-methyl-5-thioribose kinase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-85)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 10939.91 Da        Isoelectric Point: 10.7969

>T255058 WP_012668982.1 NZ_CP103450:263334-263621 [Erwinia pyrifoliae]
MIYKVKIRAEALKEWHGLDSAVREQFSKKLKKLRENPHVPSARLTGIAGCYKIKLRSSGFRLVYQVIDEELIIAVVAVGK
RERSQAYKLASERLR

Download         Length: 288 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8820.18 Da        Isoelectric Point: 4.0233

>AT255058 WP_012668983.1 NZ_CP103450:263087-263329 [Erwinia pyrifoliae]
MANLILSDTSASVSELKKNPMATVDAGCGFPVAILNRNQPAFYCIPAPLYERMLEVIDDQELVTLVKARENQPLIDLDLD

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB D2T5B9

Antitoxin

Source ID Structure
AlphaFold DB D2T5C0

References