Detailed information of TA system TA025505

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PP_4151-4152/excise(antitoxin)
• Location: 3742100..3743108
• Replicon: chromosome
• Accession: NC_015844
• Organism: Zobellia galactanivorans

Toxin (Protein)

• Gene name: PP_4152
• Uniprot ID: G0L7F3
• Locus tag: ZOBGAL_RS15300
• Protein ID: WP_013994572.1
• Coordinates: 3742545..3743108 (+)
• Length: 188 a.a.

Antitoxin (Protein)

• Gene name: PP_4151
• Uniprot ID: G0L054
• Locus tag: ZOBGAL_RS15295
• Protein ID: WP_013994571.1
• Coordinates: 3742100..3742555 (+)
• Length: 152 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
ZOBGAL_RS15265	3737135..3737755	-	621	WP_013994564.1	DUF1851 domain-containing protein	-
ZOBGAL_RS15275	3738604..3739068	-	465	WP_013994566.1	PepSY-like domain-containing protein	-
ZOBGAL_RS15285	3739891..3740301	-	411	WP_013994568.1	immunity 70 family protein	-
ZOBGAL_RS15290	3740319..3741722	-	1404	WP_013994569.1	aspartate aminotransferase family protein	-
ZOBGAL_RS15295	3742100..3742555	+	456	WP_013994571.1	helix-turn-helix domain-containing protein	Antitoxin
ZOBGAL_RS15300	3742545..3743108	+	564	WP_013994572.1	PIN domain-containing protein	Toxin
ZOBGAL_RS15305	3743243..3744067	-	825	WP_013994573.1	hypothetical protein	-
ZOBGAL_RS15310	3744422..3746848	-	2427	WP_013994575.1	TonB-dependent receptor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (9-114)

Antitoxin

• Helix-turn-helix domain, group 17 (81-125)

Sequences

Toxin

Protein

• Length: 188 a.a.
• Molecular weight: 21555.70 Da
• Isoelectric Point: 5.3370

>T25505 WP_013994572.1 NC_015844:3742545-3743108 [Zobellia galactanivorans]
MIHSVRFICVLDTNVIYPIEIRDLLFWFAHYDLYTPKWSEHIFDEWAEVMKRKGVSEEEISKRLAKANKAFPDAFVSNYS
GLISGLELPDKNDRHVLAAAIKTNANVIVTNNIKDFPKAYLSSFGLSAKTADDFLTDIIDLNPEEAIKAFKEMVLYRRNP
DLDEFEVLDILRKRGLKDTADFLHSQL

Nucleotide

• Length: 564 bp

>T25505 NC_015844:3742545-3743108 [Zobellia galactanivorans]
ATGATACATAGTGTTCGTTTTATTTGCGTATTGGATACCAATGTTATTTATCCGATCGAGATAAGGGATTTGCTTTTTTG
GTTTGCCCATTACGATTTATATACTCCTAAATGGAGCGAACATATTTTTGATGAATGGGCCGAGGTCATGAAAAGAAAAG
GAGTTTCGGAAGAAGAAATTTCTAAACGATTGGCAAAGGCTAACAAGGCATTTCCTGATGCTTTTGTTTCTAATTATTCA
GGACTTATTTCTGGATTGGAATTACCTGATAAAAATGATCGCCATGTACTTGCCGCGGCGATTAAGACCAATGCAAACGT
AATTGTCACCAACAATATAAAGGATTTTCCGAAAGCGTATTTGTCTTCTTTCGGCCTTTCCGCTAAGACCGCAGATGACT
TCTTGACCGATATTATTGATTTAAATCCTGAAGAAGCGATAAAAGCATTTAAAGAGATGGTTTTGTATCGGCGAAATCCT
GATTTAGATGAGTTTGAAGTCCTGGATATACTTAGGAAGAGGGGATTGAAAGATACCGCCGACTTTTTGCATTCGCAACT
TTGA

Antitoxin

Protein

• Length: 152 a.a.
• Molecular weight: 17034.69 Da
• Isoelectric Point: 5.7756

>AT25505 WP_013994571.1 NC_015844:3742100-3742555 [Zobellia galactanivorans]
METYNKVNKASKDEQKIAIQSYDALSSVIKGLTSDNPEIEIDETRERIKIPLSALKLLGEILEAMGKGEPFSLVPIATEV
TTQKAAEILGCSRPHLVKLLEDGKIDFTKVGKHRRVKFEDVMEYKGKMKEAQKKHLIEIMQSDEEIGLYDT

Nucleotide

• Length: 456 bp

>AT25505 NC_015844:3742100-3742555 [Zobellia galactanivorans]
ATGGAAACTTACAATAAGGTTAACAAGGCTTCAAAGGATGAGCAAAAGATTGCGATTCAATCGTATGATGCTCTTTCTTC
GGTGATTAAGGGATTGACGTCTGACAATCCTGAAATCGAGATAGATGAGACTCGGGAAAGGATTAAAATTCCATTAAGCG
CATTGAAACTTTTAGGAGAGATATTAGAAGCCATGGGTAAAGGTGAGCCATTCTCTTTGGTGCCAATTGCCACAGAGGTT
ACAACGCAAAAGGCAGCTGAAATTTTGGGTTGTTCCAGACCTCATTTGGTTAAGCTTTTAGAAGATGGGAAAATTGATTT
TACCAAAGTAGGAAAGCATCGTCGAGTTAAGTTTGAAGATGTAATGGAGTACAAGGGAAAAATGAAGGAGGCCCAGAAGA
AGCATCTTATTGAAATTATGCAATCTGACGAAGAAATCGGGTTGTATGATACATAG

Structures

Toxin

• AlphaFold DB: G0L7F3

Antitoxin

• AlphaFold DB: G0L054