Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 31530..32055 Replicon plasmid unnamed2
Accession NZ_CP103422
Organism Klebsiella variicola strain KV1

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag NYO12_RS29910 Protein ID WP_259075173.1
Coordinates 31530..31835 (-) Length 102 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag NYO12_RS29915 Protein ID WP_259075175.1
Coordinates 31837..32055 (-) Length 73 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO12_RS29885 (NYO12_29885) 27855..28610 - 756 WP_063445611.1 replication initiation protein RepE -
NYO12_RS29890 (NYO12_29890) 29135..29314 + 180 WP_259075166.1 hypothetical protein -
NYO12_RS29895 (NYO12_29895) 29462..30157 - 696 WP_259075183.1 IS6 family transposase -
NYO12_RS29900 (NYO12_29900) 30490..31281 - 792 WP_259075168.1 site-specific integrase -
NYO12_RS29905 (NYO12_29905) 31278..31409 - 132 WP_259075171.1 hypothetical protein -
NYO12_RS29910 (NYO12_29910) 31530..31835 - 306 WP_259075173.1 type II toxin-antitoxin system toxin CcdB Toxin
NYO12_RS29915 (NYO12_29915) 31837..32055 - 219 WP_259075175.1 type II toxin-antitoxin system antitoxin CcdA Antitoxin
NYO12_RS29920 (NYO12_29920) 32645..33649 + 1005 WP_259075177.1 hypothetical protein -
NYO12_RS29925 (NYO12_29925) 33929..34012 + 84 Protein_33 IS6 family transposase -
NYO12_RS29930 (NYO12_29930) 34532..35524 + 993 WP_168429828.1 hypothetical protein -
NYO12_RS29935 (NYO12_29935) 35581..35712 + 132 Protein_35 ISNCY family transposase -
NYO12_RS29940 (NYO12_29940) 35709..36320 - 612 WP_259075180.1 DUF2913 family protein -
NYO12_RS29945 (NYO12_29945) 36374..36655 - 282 WP_259075181.1 cytoplasmic protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..81805 81805


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(2-100)

Antitoxin

Post-segregation antitoxin CcdA

(2-72)


Sequences

Toxin        


Download         Length: 102 a.a.        Molecular weight: 11660.48 Da        Isoelectric Point: 5.1068

>T255046 WP_259075173.1 NZ_CP103422:c31835-31530 [Klebsiella variicola]
MQFRVYTYKRESRYRLFVDVQSDIIDTPGRRMVIPLTCARLLSDKVSRELYPVVQIGDDSYRLMTTDMASVPAPVIGEEV
ADLSVRENDIKNAINLMFWGI

Download         Length: 306 bp

Antitoxin


Download         Length: 73 a.a.        Molecular weight: 8385.33 Da        Isoelectric Point: 4.7558

>AT255046 WP_259075175.1 NZ_CP103422:c32055-31837 [Klebsiella variicola]
MKQRITVTIDSNNYQLLKEADVNISGLVNTALQNEARRLRAERWRAENQEGMAEVARFIEMNGSFADENRDW

Download         Length: 219 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References