Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /RES-TIGR02293 |
| Location | 234127..235037 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP103421 | ||
| Organism | Klebsiella variicola strain KV1 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | R4YBC5 |
| Locus tag | NYO12_RS29035 | Protein ID | WP_004144067.1 |
| Coordinates | 234127..234597 (-) | Length | 157 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A6P1V3Q9 |
| Locus tag | NYO12_RS29040 | Protein ID | WP_004026357.1 |
| Coordinates | 234594..235037 (-) | Length | 148 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| NYO12_RS29010 (NYO12_29010) | 229459..230595 | + | 1137 | WP_072046213.1 | S49 family peptidase | - |
| NYO12_RS29015 (NYO12_29015) | 230610..231371 | + | 762 | WP_227532933.1 | nuclease-related domain-containing protein | - |
| NYO12_RS29020 (NYO12_29020) | 231425..231703 | - | 279 | WP_004026336.1 | hypothetical protein | - |
| NYO12_RS29025 (NYO12_29025) | 232004..233185 | + | 1182 | WP_259075093.1 | IS481 family transposase | - |
| NYO12_RS29030 (NYO12_29030) | 233756..234016 | + | 261 | WP_080783523.1 | hypothetical protein | - |
| NYO12_RS29035 (NYO12_29035) | 234127..234597 | - | 471 | WP_004144067.1 | RES family NAD+ phosphorylase | Toxin |
| NYO12_RS29040 (NYO12_29040) | 234594..235037 | - | 444 | WP_004026357.1 | DUF2384 domain-containing protein | Antitoxin |
| NYO12_RS29045 (NYO12_29045) | 235138..236151 | - | 1014 | Protein_264 | ISL3 family transposase | - |
| NYO12_RS29050 (NYO12_29050) | 236170..236688 | - | 519 | WP_259074806.1 | ClbS/DfsB family four-helix bundle protein | - |
| NYO12_RS29055 (NYO12_29055) | 237072..238163 | - | 1092 | WP_259074809.1 | transposase | - |
| NYO12_RS29060 (NYO12_29060) | 238437..238850 | - | 414 | WP_259074811.1 | NB-ARC domain protein | - |
| NYO12_RS29065 (NYO12_29065) | 238985..239679 | + | 695 | WP_110192083.1 | IS1 family transposase | - |
| NYO12_RS29070 (NYO12_29070) | 239695..239892 | + | 198 | Protein_269 | transposase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Non-Mobilizable plasmid | - | - | 1..378475 | 378475 | |
| - | inside | IScluster/Tn | - | - | 231929..249580 | 17651 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 157 a.a. Molecular weight: 17573.83 Da Isoelectric Point: 4.5152
>T255044 WP_004144067.1 NZ_CP103421:c234597-234127 [Klebsiella variicola]
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
VILYRLTKTKYLSTAWTGYGAKEAGGRWNSVGVSMVYVSETASLTMLETLVHLHAAQIMDSFTLLSIDVPDELIQSANMD
ELPDNWADEDAPQELADYGDAWSFTRSSVALRVPSALSPVEFNYLLNPEHPEFYGIVQKAQQIPFRFDSRLKPDRK
Download Length: 471 bp
Antitoxin
Download Length: 148 a.a. Molecular weight: 16480.80 Da Isoelectric Point: 10.2498
>AT255044 WP_004026357.1 NZ_CP103421:c235037-234594 [Klebsiella variicola]
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
MKTFSLSSTPARPQRLWQVAGLNNADGVALLGQINEGLDGKVANRITDWARITQNDLRKMSGIPSTTFSRSVKARFNPEQ
SERLVRIIRVIDRAVDLFEGDKEAAQKWLNEPNRALSWKVPADLMASETGAYEVIKLITRLEHGVYS
Download Length: 444 bp
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A384IED8 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A6P1V3Q9 |