Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ataRT/DUF1778(antitoxin)
Location 166417..167168 Replicon plasmid unnamed1
Accession NZ_CP103421
Organism Klebsiella variicola strain KV1

Toxin (Protein)


Gene name ataT Uniprot ID A0A486R6L7
Locus tag NYO12_RS28705 Protein ID WP_041165502.1
Coordinates 166417..166899 (-) Length 161 a.a.

Antitoxin (Protein)


Gene name ataR Uniprot ID A0A6S4YWG5
Locus tag NYO12_RS28710 Protein ID WP_012540170.1
Coordinates 166890..167168 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO12_RS28680 (NYO12_28680) 162457..163185 - 729 WP_251895943.1 hypothetical protein -
NYO12_RS28685 (NYO12_28685) 164230..164466 + 237 WP_012540047.1 hypothetical protein -
NYO12_RS28690 (NYO12_28690) 164561..164710 - 150 WP_223884741.1 bacteriocin immunity protein -
NYO12_RS28695 (NYO12_28695) 164822..165655 - 834 WP_012540133.1 GIY-YIG nuclease family protein -
NYO12_RS28700 (NYO12_28700) 165975..166379 - 405 WP_048293664.1 DUF2251 domain-containing protein -
NYO12_RS28705 (NYO12_28705) 166417..166899 - 483 WP_041165502.1 GNAT family N-acetyltransferase Toxin
NYO12_RS28710 (NYO12_28710) 166890..167168 - 279 WP_012540170.1 DUF1778 domain-containing protein Antitoxin
NYO12_RS28715 (NYO12_28715) 167476..168012 + 537 WP_048293663.1 hypothetical protein -
NYO12_RS28720 (NYO12_28720) 169017..169331 + 315 WP_058837182.1 hypothetical protein -
NYO12_RS28725 (NYO12_28725) 169575..170057 - 483 WP_004210306.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..378475 378475


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(44-144)

Antitoxin

Vibrio phage ICP1, Orf50

(6-92)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17697.61 Da        Isoelectric Point: 9.4948

>T255043 WP_041165502.1 NZ_CP103421:c166899-166417 [Klebsiella variicola]
MGMRPPEPLTPEHNIADFCCQDQVLSEWLKKKALKNHSTGLSRVFVVCAENTNRVIAYYCLASGSVHRNTVPGAYRRNAP
EALPVIVLGRLAVDAAWARKGLGAALLKDAIYRTQHIAIQVGVRALLVHALNDEVREFYTKFGFEPSIANALTLLFPIKT

Download         Length: 483 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10749.33 Da        Isoelectric Point: 4.6722

>AT255043 WP_012540170.1 NZ_CP103421:c167168-166890 [Klebsiella variicola]
MKPDIREAPINIRAKTSQRDLIDMAANLVSKSRTDFMLEVACREAQDILLDQRLFLLDDKQFNAFVEELDAPMTPERQAR
IDNLMNRKSPWE

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A486R6L7

Antitoxin

Source ID Structure
AlphaFold DB A0A6S4YWG5

References