Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 123934..124670 Replicon plasmid unnamed1
Accession NZ_CP103421
Organism Klebsiella variicola strain KV1

Toxin (Protein)


Gene name tacT Uniprot ID -
Locus tag NYO12_RS28485 Protein ID WP_259075028.1
Coordinates 124188..124670 (+) Length 161 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID -
Locus tag NYO12_RS28480 Protein ID WP_049083184.1
Coordinates 123934..124200 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO12_RS28455 (NYO12_28455) 119533..120411 - 879 WP_080895811.1 hypothetical protein -
NYO12_RS28460 (NYO12_28460) 120408..120857 - 450 WP_072046253.1 NUDIX domain-containing protein -
NYO12_RS28465 (NYO12_28465) 120854..122026 - 1173 WP_110191897.1 DegT/DnrJ/EryC1/StrS family aminotransferase -
NYO12_RS28470 (NYO12_28470) 122274..123023 - 750 WP_080783468.1 SDR family oxidoreductase -
NYO12_RS28475 (NYO12_28475) 123481..123693 + 213 WP_226908518.1 cell envelope integrity protein TolA -
NYO12_RS28480 (NYO12_28480) 123934..124200 + 267 WP_049083184.1 DUF1778 domain-containing protein Antitoxin
NYO12_RS28485 (NYO12_28485) 124188..124670 + 483 WP_259075028.1 GNAT family N-acetyltransferase Toxin
NYO12_RS28490 (NYO12_28490) 124848..126251 + 1404 WP_259075030.1 ISNCY family transposase -
NYO12_RS28495 (NYO12_28495) 126284..126907 - 624 Protein_154 arsenical resistance protein ArsH -
NYO12_RS28500 (NYO12_28500) 127074..127394 + 321 WP_000941305.1 transcriptional regulator -
NYO12_RS28505 (NYO12_28505) 127440..128729 + 1290 WP_000922628.1 arsenic transporter -
NYO12_RS28510 (NYO12_28510) 128742..129167 + 426 WP_000065802.1 glutaredoxin-dependent arsenate reductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..378475 378475
- flank IS/Tn - - 118733..119428 695
- flank IS/Tn - - 124848..126251 1403


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(56-149)

Antitoxin

Vibrio phage ICP1, Orf50

(2-87)


Sequences

Toxin        


Download         Length: 161 a.a.        Molecular weight: 17240.87 Da        Isoelectric Point: 8.7400

>T255042 WP_259075028.1 NZ_CP103421:124188-124670 [Klebsiella variicola]
VGCITAPEPLSSAHQLADFVSGETVLDEWLKQRGLKNQALGAARTFVVCKTGTKQVAGFYSLATGSVNHTEATGSLRRNM
PDPIPVIILARLAVDVSLHGKGVGADLLHDAVLRCYRVAENIGVRAIMVHALTEEAKGFYAHHGFKASQTHERTLFLKLP

Download         Length: 483 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10117.61 Da        Isoelectric Point: 4.6437

>AT255042 WP_049083184.1 NZ_CP103421:123934-124200 [Klebsiella variicola]
MKSDVQLNLRAKESQRALIDAAAEILHKSRTDFILEMACKAAENVILDRRVFNFNDVQYAEFIDMLDAPVEDEPAINKLL
ARKPQWDV

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References