Detailed information of TA system TA255039

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): mosAT/AbiEii-AbiEi
• Location: 5208014..5209695
• Replicon: chromosome
• Accession: NZ_CP103420
• Organism: Klebsiella variicola strain KV1

Toxin (Protein)

• Gene name: mosT
• Uniprot ID: -
• Locus tag: NYO12_RS25850
• Protein ID: WP_110193166.1
• Coordinates: 5208014..5208931 (-)
• Length: 306 a.a.

Antitoxin (Protein)

• Gene name: mosA
• Uniprot ID: -
• Locus tag: NYO12_RS25855
• Protein ID: WP_110193167.1
• Coordinates: 5208937..5209695 (-)
• Length: 253 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
NYO12_RS25830 (5203320)	5203320..5204840	+	1521	WP_008807253.1	sugar ABC transporter ATP-binding protein	-
NYO12_RS25835 (5204837)	5204837..5205835	+	999	WP_049162519.1	COG4158 family protein	-
NYO12_RS25840 (5205866)	5205866..5206807	+	942	WP_012543155.1	ABC transporter substrate-binding protein	-
NYO12_RS25845 (5206882)	5206882..5207889	+	1008	WP_023339423.1	carbohydrate kinase family protein	-
NYO12_RS25850 (5208014)	5208014..5208931	-	918	WP_110193166.1	nucleotidyl transferase AbiEii/AbiGii toxin family protein	Toxin
NYO12_RS25855 (5208937)	5208937..5209695	-	759	WP_110193167.1	type IV toxin-antitoxin system AbiEi family antitoxin	Antitoxin
NYO12_RS25860 (5209780)	5209780..5210508	-	729	WP_008807258.1	response regulator transcription factor	-
NYO12_RS25865 (5210781)	5210781..5212928	+	2148	WP_077625405.1	formate dehydrogenase subunit alpha	-
NYO12_RS25870 (5213370)	5213370..5214056	+	687	WP_016160120.1	tetratricopeptide repeat protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Nucleotidyl transferase AbiEii toxin, Type IV TA system (14-278)

Antitoxin

• Transcriptional regulator AbiEi antitoxin, N-terminal domain (1-93)

Sequences

Toxin

Protein

• Length: 306 a.a.
• Molecular weight: 34748.18 Da
• Isoelectric Point: 5.7844

>T255039 WP_110193166.1 NZ_CP103420:c5208931-5208014 [Klebsiella variicola]
MDIQAPYYRQVALLMQVLPYVAVEREFALKGGTAINLFIRDFPRLSVDIDLAWVPLESRAIALPHIRDALARIAANLQQQ
AGMNAVLQANRSDEMRVVVTTDSAQIKIEVSPVARGTLYPPQEREVVGAVEDVFGYASLPVVSLPDLYGGKLCAALDRQH
PRDFYDVKLLLDAQELNRPIFNGFIAYLLSHNRPLAEVLSPRWKDIAEPFYREFSGMTFETIALEELKAVPYRMIDALKS
CFTQQDIDFLLSFKRGEPDWRLAPETRIQDLPAVQWKLRNIHQMPAIKRAESLDKLEKVLAEWRS

Nucleotide

• Length: 918 bp

Antitoxin

Protein

• Length: 253 a.a.
• Molecular weight: 28701.06 Da
• Isoelectric Point: 10.1988

>AT255039 WP_110193167.1 NZ_CP103420:c5209695-5208937 [Klebsiella variicola]
MPSKLNWLLQNSAPGDVILQSWLSRHAISPSLAFKYTQSGWLKKRGNGVYARAGREPEWNDALACLQNQLAAPVYVAGLS
SLVWQGRSHYLQLKQNQCWLSMENKALLPKWFREFPGVEWIVISGQKLPVLDDKYRVTLDVKGKRLTGSAPELAAYELLS
AVPGTLSFNHAAELFQGLFNLNPRKVEYLLSVSQSVQTKRLYLFFASFYEHGWLRRIDSQKIDLGAGKRQIVVNGKFNAQ
YQITVPERFQKE

Nucleotide

• Length: 759 bp