Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) shpAB/BrnT-BrnA
Location 4948189..4948765 Replicon chromosome
Accession NZ_CP103420
Organism Klebsiella variicola strain KV1

Toxin (Protein)


Gene name shpA Uniprot ID -
Locus tag NYO12_RS24620 Protein ID WP_012542979.1
Coordinates 4948478..4948765 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name shpB Uniprot ID -
Locus tag NYO12_RS24615 Protein ID WP_022065028.1
Coordinates 4948189..4948491 (-) Length 101 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO12_RS24590 (4943605) 4943605..4944669 - 1065 WP_042947982.1 DUF2955 domain-containing protein -
NYO12_RS24595 (4944659) 4944659..4945726 - 1068 WP_039102796.1 HlyD family secretion protein -
NYO12_RS24600 (4945733) 4945733..4946197 - 465 WP_012969020.1 MarR family transcriptional regulator -
NYO12_RS24605 (4946363) 4946363..4946527 - 165 WP_008807599.1 DUF1127 domain-containing protein -
NYO12_RS24610 (4946705) 4946705..4948117 + 1413 WP_008807600.1 PLP-dependent aminotransferase family protein -
NYO12_RS24615 (4948189) 4948189..4948491 - 303 WP_022065028.1 BrnA antitoxin family protein Antitoxin
NYO12_RS24620 (4948478) 4948478..4948765 - 288 WP_012542979.1 BrnT family toxin Toxin
NYO12_RS24625 (4948933) 4948933..4949356 - 424 Protein_4837 FosA5 family fosfomycin resistance glutathione transferase -
NYO12_RS24630 (4949350) 4949350..4950258 - 909 WP_023339531.1 LysR family transcriptional regulator -
NYO12_RS24635 (4950345) 4950345..4951127 + 783 WP_016160218.1 NAD(P)H-dependent oxidoreductase -
NYO12_RS24640 (4951165) 4951165..4952121 - 957 WP_016160217.1 ABC transporter permease -
NYO12_RS24645 (4952118) 4952118..4953089 - 972 WP_008807605.1 ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(38-93)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11245.77 Da        Isoelectric Point: 8.6574

>T255038 WP_012542979.1 NZ_CP103420:c4948765-4948478 [Klebsiella variicola]
MPMEFEWDANKALSNLRKHGVRFEEAVLVFDDPRHLSRQERFENGEYRWQTIGLVHGILVILVAHSVRFESGTEVIRIIS
ARKADRKERNRYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 101 a.a.        Molecular weight: 11320.98 Da        Isoelectric Point: 10.3129

>AT255038 WP_022065028.1 NZ_CP103420:c4948491-4948189 [Klebsiella variicola]
MSMVKHKRGNTAALTAKRDAELKALASKADEDIDYSDIPATDDAQWSDAVRGKFFRPLKTQASVRIDADVMEWLKRPGKG
YQTRLNAILREAMIRDLNKK

Download         Length: 303 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References