Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2827388..2828976 Replicon chromosome
Accession NZ_CP103420
Organism Klebsiella variicola strain KV1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYO12_RS14190 Protein ID WP_044643526.1
Coordinates 2827388..2828710 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag NYO12_RS14195 Protein ID WP_008804920.1
Coordinates 2828710..2828976 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO12_RS14175 (2822453) 2822453..2824954 + 2502 WP_259068833.1 fimbria/pilus outer membrane usher protein -
NYO12_RS14180 (2824942) 2824942..2825946 + 1005 WP_039103406.1 fimbrial protein -
NYO12_RS14185 (2826079) 2826079..2827371 + 1293 WP_012541751.1 glycoside hydrolase family 10 protein -
NYO12_RS14190 (2827388) 2827388..2828710 - 1323 WP_044643526.1 type II toxin-antitoxin system HipA family toxin Toxin
NYO12_RS14195 (2828710) 2828710..2828976 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NYO12_RS14200 (2829363) 2829363..2829689 - 327 WP_008804921.1 hydroxyisourate hydrolase -
NYO12_RS14205 (2829686) 2829686..2830186 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NYO12_RS14210 (2830164) 2830164..2831543 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
NYO12_RS14215 (2831889) 2831889..2833043 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
NYO12_RS14220 (2833024) 2833024..2833947 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - iroE 2631318..2866115 234797


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48939.32 Da        Isoelectric Point: 7.9109

>T255036 WP_044643526.1 NZ_CP103420:c2828710-2827388 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEVHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT255036 WP_008804920.1 NZ_CP103420:c2828976-2828710 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References