Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemIK/PRK09812-MazE
Location 1872192..1872782 Replicon chromosome
Accession NZ_CP103420
Organism Klebsiella variicola strain KV1

Toxin (Protein)


Gene name pemK Uniprot ID -
Locus tag NYO12_RS09235 Protein ID WP_023322934.1
Coordinates 1872450..1872782 (+) Length 111 a.a.

Antitoxin (Protein)


Gene name pemI Uniprot ID A0A1F2LZQ3
Locus tag NYO12_RS09230 Protein ID WP_012541132.1
Coordinates 1872192..1872449 (+) Length 86 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO12_RS09210 (1867802) 1867802..1868377 + 576 WP_023322936.1 hypothetical protein -
NYO12_RS09215 (1868554) 1868554..1869390 + 837 WP_008804155.1 alpha/beta hydrolase -
NYO12_RS09220 (1869597) 1869597..1870568 + 972 WP_016161433.1 sensor domain-containing diguanylate cyclase -
NYO12_RS09225 (1870565) 1870565..1871665 - 1101 WP_087653750.1 AarF/UbiB family protein -
NYO12_RS09230 (1872192) 1872192..1872449 + 258 WP_012541132.1 antitoxin Antitoxin
NYO12_RS09235 (1872450) 1872450..1872782 + 333 WP_023322934.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NYO12_RS09245 (1873105) 1873105..1874541 + 1437 WP_016161429.1 EmmdR/YeeO family multidrug/toxin efflux MATE transporter -
NYO12_RS09255 (1874914) 1874914..1876368 - 1455 WP_259073653.1 AMP nucleosidase -
NYO12_RS09260 (1876499) 1876499..1876744 - 246 WP_008804171.1 signal transduction protein PmrD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(3-108)

Antitoxin

Antitoxin PemI-like

(4-84)


Sequences

Toxin        


Download         Length: 111 a.a.        Molecular weight: 11768.58 Da        Isoelectric Point: 9.2926

>T255031 WP_023322934.1 NZ_CP103420:1872450-1872782 [Klebsiella variicola]
MDRGEIWLVSLDPIAGHEQSGKRPVLIVSKASFNKLTRLPVVVPVTSGGNFARTAGFTVSLEEAGTKTTGVIRCDQPGTI
DMAARNGKRLERIPDAVVNEVLARLDAILS

Download         Length: 333 bp

Antitoxin


Download         Length: 86 a.a.        Molecular weight: 9420.91 Da        Isoelectric Point: 4.4915

>AT255031 WP_012541132.1 NZ_CP103420:1872192-1872449 [Klebsiella variicola]
MYKTRLKKVGGSIMLAVPPAVLKALELSTDSEVGMTIDNGCLIIEPQKRPHYSLEELLAQCDPHAEMSEEDREWIDAPAV
GKEIL

Download         Length: 258 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2LZQ3

References