Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1687839..1688836 Replicon chromosome
Accession NZ_CP103420
Organism Klebsiella variicola strain KV1

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYO12_RS08455 Protein ID WP_229531768.1
Coordinates 1688282..1688836 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MDT5
Locus tag NYO12_RS08450 Protein ID WP_012541033.1
Coordinates 1687839..1688285 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO12_RS08435 (1684134) 1684134..1685132 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
NYO12_RS08440 (1685251) 1685251..1686771 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
NYO12_RS08445 (1686787) 1686787..1687797 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
NYO12_RS08450 (1687839) 1687839..1688285 - 447 WP_012541033.1 helix-turn-helix transcriptional regulator Antitoxin
NYO12_RS08455 (1688282) 1688282..1688836 - 555 WP_229531768.1 HipA domain-containing protein Toxin
NYO12_RS08460 (1688865) 1688865..1689386 - 522 WP_023297992.1 hypothetical protein -
NYO12_RS08465 (1689501) 1689501..1690232 - 732 WP_008804033.1 outer membrane permeability protein SanA -
NYO12_RS08470 (1690525) 1690525..1691409 - 885 WP_012967554.1 cytidine deaminase -
NYO12_RS08475 (1691538) 1691538..1692233 - 696 WP_259073400.1 CidB/LrgB family autolysis modulator -
NYO12_RS08480 (1692223) 1692223..1692627 - 405 WP_004201620.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20710.03 Da        Isoelectric Point: 5.7891

>T255030 WP_229531768.1 NZ_CP103420:c1688836-1688282 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFAPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16396.05 Da        Isoelectric Point: 10.5417

>AT255030 WP_012541033.1 NZ_CP103420:c1688285-1687839 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MDT5

References