Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-HipB
Location 2727480..2729068 Replicon chromosome
Accession NZ_CP103419
Organism Klebsiella variicola strain KV4

Toxin (Protein)


Gene name hipA Uniprot ID A0A1F2MCM0
Locus tag NYO13_RS13200 Protein ID WP_008804919.1
Coordinates 2727480..2728802 (-) Length 441 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MCN9
Locus tag NYO13_RS13205 Protein ID WP_008804920.1
Coordinates 2728802..2729068 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO13_RS13185 (NYO13_13185) 2722545..2725046 + 2502 WP_048330153.1 fimbria/pilus outer membrane usher protein -
NYO13_RS13190 (NYO13_13190) 2725034..2726038 + 1005 WP_048330151.1 fimbrial protein -
NYO13_RS13195 (NYO13_13195) 2726171..2727463 + 1293 WP_012968243.1 glycoside hydrolase family 10 protein -
NYO13_RS13200 (NYO13_13200) 2727480..2728802 - 1323 WP_008804919.1 type II toxin-antitoxin system HipA family toxin Toxin
NYO13_RS13205 (NYO13_13205) 2728802..2729068 - 267 WP_008804920.1 type II toxin-antitoxin system antitoxin HipB Antitoxin
NYO13_RS13210 (NYO13_13210) 2729334..2729660 - 327 WP_008804921.1 hydroxyisourate hydrolase -
NYO13_RS13215 (NYO13_13215) 2729657..2730157 - 501 WP_008804922.1 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase -
NYO13_RS13220 (NYO13_13220) 2730135..2731514 - 1380 WP_012968246.1 nucleobase:cation symporter-2 family protein -
NYO13_RS13225 (NYO13_13225) 2731860..2733014 + 1155 WP_008804924.1 FAD-dependent urate hydroxylase HpxO -
NYO13_RS13230 (NYO13_13230) 2732995..2733918 - 924 WP_008804925.1 LysR family hpxDE operon transcriptional regulator HpxR -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA, N-terminal subdomain 1

(5-103)

Antitoxin

Cro/C1-type helix-turn-helix domain

(13-65)


Sequences

Toxin        


Download         Length: 441 a.a.        Molecular weight: 48911.26 Da        Isoelectric Point: 7.9109

>T255023 WP_008804919.1 NZ_CP103419:c2728802-2727480 [Klebsiella variicola]
MATLTTWMNNVRVGTLTRQANGAHSFRYDEEWLRSPRARPLSLSLPLQYGNITADAVYHYFDNLLPDSPQVRDRIVRRYQ
ARSKQPFDLLAEVGRDSVGAVTLLPPGEEAHLEGLRWQTLDEAQLTALLTAYQSDIPLGMITGQDDFRISVAGAQEKTAL
LRMGGHWCIPQGTTPTTHIIKLPIGEIKQPNATLDLRESVDNEFLCLALARELGLAVPEAEIITTPRIRALAVTRFDRRW
AQEGRVLLRLPQEDLCQAFGIPSSMKYESDGGPGIAAIMAFLLGSSEALKDRADFMKFMVFQWLVGATDGHAKNFSLFLL
PGGSYRLTPFYDIISAFPVLGGTGLHLRDLKLSMGLNATKGRKTEINAIYPRHFLATAKAVNFPGEQMLAILQEFAGHVP
QAIESARRTLPADFSTHVWRAITENMLKLHARLQQGLQAL

Download         Length: 1323 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9936.30 Da        Isoelectric Point: 8.5912

>AT255023 WP_008804920.1 NZ_CP103419:c2729068-2728802 [Klebsiella variicola]
MNSPQIYSPVQLANYLKLLRQQNHWTQDALARRIGIKQATLSNFENHPDKTTLTTLFKILQSLGVVMTLNAKATETAPAP
DNNTDLDW

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1F2MCM0

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MCN9

References