Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hipBA/HipA-couple_hipB
Location 1608593..1609590 Replicon chromosome
Accession NZ_CP103419
Organism Klebsiella variicola strain KV4

Toxin (Protein)


Gene name hipA Uniprot ID -
Locus tag NYO13_RS07795 Protein ID WP_242629669.1
Coordinates 1609036..1609590 (-) Length 185 a.a.

Antitoxin (Protein)


Gene name hipB Uniprot ID A0A1F2MDT5
Locus tag NYO13_RS07790 Protein ID WP_012541033.1
Coordinates 1608593..1609039 (-) Length 149 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO13_RS07775 (NYO13_07775) 1604888..1605886 + 999 WP_008804028.1 galactose/glucose ABC transporter substrate-binding protein MglB -
NYO13_RS07780 (NYO13_07780) 1606005..1607525 + 1521 WP_008804029.1 galactose/methyl galactoside ABC transporter ATP-binding protein MglA -
NYO13_RS07785 (NYO13_07785) 1607541..1608551 + 1011 WP_002912871.1 galactose/methyl galactoside ABC transporter permease MglC -
NYO13_RS07790 (NYO13_07790) 1608593..1609039 - 447 WP_012541033.1 helix-turn-helix transcriptional regulator Antitoxin
NYO13_RS07795 (NYO13_07795) 1609036..1609590 - 555 WP_242629669.1 HipA domain-containing protein Toxin
NYO13_RS07800 (NYO13_07800) 1609619..1610140 - 522 WP_022064813.1 hypothetical protein -
NYO13_RS07805 (NYO13_07805) 1610255..1610986 - 732 WP_008804033.1 outer membrane permeability protein SanA -
NYO13_RS07810 (NYO13_07810) 1611023..1611241 - 219 WP_048331011.1 hypothetical protein -
NYO13_RS07815 (NYO13_07815) 1611263..1612147 - 885 WP_012967554.1 cytidine deaminase -
NYO13_RS07820 (NYO13_07820) 1612276..1612971 - 696 WP_008804035.1 CidB/LrgB family autolysis modulator -
NYO13_RS07825 (NYO13_07825) 1612961..1613365 - 405 WP_048331009.1 CidA/LrgA family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HipA-like, C-terminal

(2-147)

Antitoxin

Cro/C1-type helix-turn-helix domain

(78-132)


Sequences

Toxin        


Download         Length: 185 a.a.        Molecular weight: 20726.03 Da        Isoelectric Point: 5.7891

>T255016 WP_242629669.1 NZ_CP103419:c1609590-1609036 [Klebsiella variicola]
MRLGMESVYSLLQKAPATILDHETTLRILIEKITSSNMVRVQNYRFDVQGFIIDWVRRDLLNIIFGNSDNHGRNTAFMKA
DNEIILAPIYDFSPMKADPEGIPRTMKWSLACESGGEYNFGAIAQALAEWITPDTLLNALSETASQLVDLPSRLKVRGVP
VQILEMPSIGFKFIPDKLARWGLL

Download         Length: 555 bp

Antitoxin


Download         Length: 149 a.a.        Molecular weight: 16396.05 Da        Isoelectric Point: 10.5417

>AT255016 WP_012541033.1 NZ_CP103419:c1609039-1608593 [Klebsiella variicola]
MKTLNKKETEIQNTLARLRADNPPSLPATGVTATEKKARSEISRQRVSAGLKKVKTVDRQAVIHAIIHDIMLGAISQGEA
LKKLRVEVLGLRQDEYARLVDVSRKTLSDVENDKGNYSAEIINKIYKPFGLETGLVPISKTLISSLFK

Download         Length: 447 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A1F2MDT5

References