Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 795239..795896 Replicon chromosome
Accession NZ_CP103419
Organism Klebsiella variicola strain KV4

Toxin (Protein)


Gene name cptA Uniprot ID W8UCT0
Locus tag NYO13_RS03905 Protein ID WP_002916310.1
Coordinates 795486..795896 (+) Length 137 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag NYO13_RS03900 Protein ID WP_002916312.1
Coordinates 795239..795505 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYO13_RS03875 (NYO13_03875) 790284..791717 - 1434 WP_008806432.1 6-phospho-beta-glucosidase BglA -
NYO13_RS03880 (NYO13_03880) 791837..792565 - 729 WP_032701093.1 MurR/RpiR family transcriptional regulator -
NYO13_RS03885 (NYO13_03885) 792616..792927 + 312 WP_048330660.1 N(4)-acetylcytidine aminohydrolase -
NYO13_RS03890 (NYO13_03890) 793091..793750 + 660 WP_008806429.1 hemolysin III family protein -
NYO13_RS03895 (NYO13_03895) 794010..794993 - 984 WP_008806428.1 tRNA-modifying protein YgfZ -
NYO13_RS03900 (NYO13_03900) 795239..795505 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
NYO13_RS03905 (NYO13_03905) 795486..795896 + 411 WP_002916310.1 protein YgfX Toxin
NYO13_RS03910 (NYO13_03910) 795903..796424 - 522 WP_008806427.1 flavodoxin FldB -
NYO13_RS03915 (NYO13_03915) 796525..797421 + 897 WP_259144995.1 site-specific tyrosine recombinase XerD -
NYO13_RS03920 (NYO13_03920) 797444..798157 + 714 WP_008806425.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NYO13_RS03925 (NYO13_03925) 798163..799896 + 1734 WP_259144996.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-132)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 137 a.a.        Molecular weight: 16049.85 Da        Isoelectric Point: 11.4778

>T255015 WP_002916310.1 NZ_CP103419:795486-795896 [Klebsiella variicola]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNA
EWEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 411 bp

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT255015 WP_002916312.1 NZ_CP103419:795239-795505 [Klebsiella variicola]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GSW7

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References