Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1296674..1297591 Replicon chromosome
Accession NZ_CP103412
Organism Bacillus velezensis strain HF-14109

Toxin (Protein)


Gene name spoIISA Uniprot ID -
Locus tag NX856_RS06945 Protein ID WP_032866111.1
Coordinates 1296845..1297591 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID I2HQ14
Locus tag NX856_RS06940 Protein ID WP_003154807.1
Coordinates 1296674..1296844 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX856_RS06900 (1291886) 1291886..1293475 + 1590 WP_205164551.1 hypothetical protein -
NX856_RS06905 (1293488) 1293488..1293913 + 426 WP_050498185.1 hypothetical protein -
NX856_RS06910 (1293918) 1293918..1294115 + 198 WP_007610833.1 XkdX family protein -
NX856_RS06915 (1294172) 1294172..1294933 + 762 WP_020955694.1 hypothetical protein -
NX856_RS06920 (1294985) 1294985..1295248 + 264 WP_003154815.1 hemolysin XhlA family protein -
NX856_RS06925 (1295262) 1295262..1295525 + 264 WP_003154813.1 phage holin -
NX856_RS06930 (1295539) 1295539..1296417 + 879 WP_020955695.1 N-acetylmuramoyl-L-alanine amidase -
NX856_RS06935 (1296452) 1296452..1296577 - 126 WP_023356844.1 hypothetical protein -
NX856_RS06940 (1296674) 1296674..1296844 - 171 WP_003154807.1 type II toxin-antitoxin system SpoIISB family antitoxin Antitoxin
NX856_RS06945 (1296845) 1296845..1297591 - 747 WP_032866111.1 type II toxin-antitoxin system SpoIISA family toxin Toxin
NX856_RS06950 (1297695) 1297695..1298693 - 999 WP_020955696.1 inorganic phosphate transporter -
NX856_RS06955 (1298706) 1298706..1299323 - 618 WP_003154804.1 DUF47 domain-containing protein -
NX856_RS06960 (1299609) 1299609..1300925 - 1317 WP_007407254.1 amino acid permease -
NX856_RS06965 (1301248) 1301248..1302198 + 951 WP_218791607.1 ring-cleaving dioxygenase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1261670..1305848 44178


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-239)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29095.60 Da        Isoelectric Point: 4.7755

>T255008 WP_032866111.1 NZ_CP103412:c1297591-1296845 [Bacillus velezensis]
MLMFFQIMVWTMAAALILYVYASWRYEAKVKEKMFAIRKTWYLLFVLGSMVYWTYDPESLFAAWRQYLIVAVCFALIDAF
IFLSAYIKKLAGNELETDTREILEENNEMLHSYLEKLKTYQYLLKNEPIHVYYGSTEAYAEGISRLLAAYAEKMNVTASL
CDYSAQSDKDRLTEHMPDAADVQSRLNRKDVYYDQKGRLVLIPFTVQNRHYVIKLTSENLLTEFDYLLFTSLTSIYDLML
PIEEEGDG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6676.74 Da        Isoelectric Point: 10.9273

>AT255008 WP_003154807.1 NZ_CP103412:c1296844-1296674 [Bacillus velezensis]
MEQAFQNGQPEQRAKPFKMFKKRSMTSIASYQVSPHTARIFKENERLIDKYKQKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB I2HQ14

References