Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicB
Location 3303699..3304324 Replicon chromosome
Accession NZ_CP103401
Organism Pantoea agglomerans strain CHTF15

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag NYF24_RS15615 Protein ID WP_158149559.1
Coordinates 3304145..3304324 (-) Length 60 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag NYF24_RS15610 Protein ID WP_158149558.1
Coordinates 3303699..3304118 (-) Length 140 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NYF24_RS15580 (3298817) 3298817..3299326 - 510 WP_039391324.1 phenolic acid decarboxylase -
NYF24_RS15585 (3299432) 3299432..3300331 + 900 WP_158149554.1 LysR family transcriptional regulator -
NYF24_RS15590 (3300352) 3300352..3300735 - 384 WP_115764296.1 hypothetical protein -
NYF24_RS15595 (3300921) 3300921..3302243 + 1323 WP_179256891.1 DUF4062 domain-containing protein -
NYF24_RS15600 (3302357) 3302357..3303286 - 930 WP_158149556.1 Rpn family recombination-promoting nuclease/putative transposase -
NYF24_RS15605 (3303522) 3303522..3303611 - 90 Protein_3038 CRISPR-associated protein Cas1 -
NYF24_RS15610 (3303699) 3303699..3304118 - 420 WP_158149558.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NYF24_RS15615 (3304145) 3304145..3304324 - 180 WP_158149559.1 type II toxin-antitoxin system HicA family toxin Toxin
NYF24_RS15620 (3304507) 3304507..3305931 - 1425 WP_010253950.1 dihydrolipoyl dehydrogenase -
NYF24_RS15625 (3306092) 3306092..3307993 - 1902 WP_010671838.1 pyruvate dehydrogenase complex dihydrolipoyllysine-residue acetyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(5-58)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(3-128)


Sequences

Toxin        


Download         Length: 60 a.a.        Molecular weight: 6581.67 Da        Isoelectric Point: 10.7838

>T254997 WP_158149559.1 NZ_CP103401:c3304324-3304145 [Pantoea agglomerans]
MDSSTLISEMKADGWVLTRIDGSHHHFTHPTKPGLVTIPHPKKDLPIGTVKSIRKQARI

Download         Length: 180 bp

Antitoxin


Download         Length: 140 a.a.        Molecular weight: 15166.29 Da        Isoelectric Point: 4.6215

>AT254997 WP_158149558.1 NZ_CP103401:c3304118-3303699 [Pantoea agglomerans]
MFYPIAIEAGDHEHAYGVIVPDLPGCFSAGDTLDEAIKNAKEAITGHIELCVELGHEIPAVSTIETLATNPDYQGYIWAL
VDVDVIRLLGGSEKINVTLPRSLIDRIDRCVASHPEYKSRSGFLAQVALERITAPINRP

Download         Length: 420 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References