Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pemK-mazE/MazF(toxin)
Location 2184115..2184744 Replicon chromosome
Accession NZ_CP103399
Organism Listeria innocua strain F6215

Toxin (Protein)


Gene name pemK Uniprot ID Q92DC7
Locus tag NVV71_RS11440 Protein ID WP_010990666.1
Coordinates 2184115..2184462 (-) Length 116 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID H1GC21
Locus tag NVV71_RS11445 Protein ID WP_003761302.1
Coordinates 2184466..2184744 (-) Length 93 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NVV71_RS11405 (NVV71_11405) 2179524..2180303 - 780 WP_070753401.1 RNA polymerase sigma factor SigB -
NVV71_RS11410 (NVV71_11410) 2180281..2180754 - 474 WP_003761314.1 anti-sigma B factor RsbW -
NVV71_RS11415 (NVV71_11415) 2180738..2181082 - 345 WP_003721460.1 anti sigma b factor antagonist RsbV -
NVV71_RS11420 (NVV71_11420) 2181232..2182236 - 1005 WP_070753402.1 PP2C family protein-serine/threonine phosphatase -
NVV71_RS11425 (NVV71_11425) 2182253..2182663 - 411 WP_010990667.1 anti-sigma regulatory factor -
NVV71_RS11430 (NVV71_11430) 2182666..2183022 - 357 WP_003721457.1 STAS domain-containing protein -
NVV71_RS11435 (NVV71_11435) 2183028..2183864 - 837 WP_003771126.1 STAS domain-containing protein -
NVV71_RS11440 (NVV71_11440) 2184115..2184462 - 348 WP_010990666.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
NVV71_RS11445 (NVV71_11445) 2184466..2184744 - 279 WP_003761302.1 CopG family ribbon-helix-helix protein Antitoxin
NVV71_RS11450 (NVV71_11450) 2184950..2186056 - 1107 WP_187989047.1 alanine racemase -
NVV71_RS11455 (NVV71_11455) 2186075..2186431 - 357 WP_003761296.1 holo-ACP synthase -
NVV71_RS11460 (NVV71_11460) 2186433..2187812 - 1380 WP_070753404.1 protoporphyrinogen oxidase -
NVV71_RS11465 (NVV71_11465) 2187963..2189447 - 1485 WP_070753405.1 PH domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(4-109)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 116 a.a.        Molecular weight: 12801.85 Da        Isoelectric Point: 6.4735

>T254991 WP_010990666.1 NZ_CP103399:c2184462-2184115 [Listeria innocua]
MMVKRGDVYYADLSPVVGSEQGGIRPVLIIQNDIGNRFSPTVIVAAITAKIQKAKLPTHVEATRKDGFERDSVILLEQIR
TIDKQRLTDKITHLDEELMAKVNQALEVSLGVVEF

Download         Length: 348 bp

Antitoxin


Download         Length: 93 a.a.        Molecular weight: 10605.13 Da        Isoelectric Point: 4.2980

>AT254991 WP_003761302.1 NZ_CP103399:c2184744-2184466 [Listeria innocua]
VLEKEKRMIISVELTQEMVQELDVVVEKEKMGRSEVIMEATQQFLQEKRARELRDEMERGYAEMATINFAIACECTHVEA
EAEDRNISILGG

Download         Length: 279 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1E7E4N0

Antitoxin

Source ID Structure
AlphaFold DB H1GC21

References