Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) spoIISABC/SpoIISA-SpoIISB
Location 1321256..1322172 Replicon chromosome
Accession NZ_CP103350
Organism Bacillus subtilis strain SRCM117108

Toxin (Protein)


Gene name spoIISA Uniprot ID O34853
Locus tag NX810_RS06935 Protein ID WP_003244695.1
Coordinates 1321426..1322172 (-) Length 249 a.a.

Antitoxin (Protein)


Gene name spoIISB Uniprot ID G4EXD8
Locus tag NX810_RS06930 Protein ID WP_003232646.1
Coordinates 1321256..1321426 (-) Length 57 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX810_RS06895 (1318122) 1318122..1318448 + 327 WP_029727046.1 XkdW family protein -
NX810_RS06900 (1318445) 1318445..1318609 + 165 WP_014479563.1 XkdX family protein -
NX810_RS06905 (1318653) 1318653..1319492 + 840 WP_029727045.1 phage-like element PBSX protein XepA -
NX810_RS06910 (1319545) 1319545..1319814 + 270 WP_015252265.1 hemolysin XhlA family protein -
NX810_RS06915 (1319827) 1319827..1320090 + 264 WP_014479566.1 phage holin -
NX810_RS06920 (1320103) 1320103..1320996 + 894 WP_029727044.1 N-acetylmuramoyl-L-alanine amidase -
NX810_RS06925 (1321033) 1321033..1321170 - 138 WP_119899277.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISC -
NX810_RS06930 (1321256) 1321256..1321426 - 171 WP_003232646.1 three component toxin-antitoxin-antitoxin system antitoxin SpoIISB Antitoxin
NX810_RS06935 (1321426) 1321426..1322172 - 747 WP_003244695.1 toxin-antitoxin-antitoxin system toxin SpoIISA Toxin
NX810_RS06940 (1322282) 1322282..1323283 - 1002 WP_003232642.1 inorganic phosphate transporter -
NX810_RS06945 (1323296) 1323296..1323913 - 618 WP_003218470.1 DUF47 domain-containing protein -
NX810_RS06950 (1324189) 1324189..1325505 - 1317 WP_015252262.1 serine/threonine exchanger -
NX810_RS06955 (1325893) 1325893..1326843 + 951 WP_003232637.1 VOC family protein -
NX810_RS06960 (1326952) 1326952..1327047 + 96 Protein_1307 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 1285798..1342617 56819


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SpoIISA, type II toxin-antitoxin system

(3-238)

Antitoxin

Antitoxin SpoIISB

(1-56)


Sequences

Toxin        


Download         Length: 249 a.a.        Molecular weight: 29061.50 Da        Isoelectric Point: 4.6191

>T254976 WP_003244695.1 NZ_CP103350:c1322172-1321426 [Bacillus subtilis]
MVLFFQIMVWCIVAGLGLYVYATWRFEAKVKEKMSAIRKTWYLLFVLGAMVYWTYEPTSLFTHWERYLIVAVSFALIDAF
IFLSAYVKKLAGSELETDTREILEENNEMLHMYLNRLKTYQYLLKNEPIHVYYGSIDAYAEGIDKLLKTYADKMNLTASL
CHYSTQADKDRLTEHMDDPADVQTRLDRKDVYYDQYGKVVLIPFTIETQNYVIKLTSDSIVTEFDYLLFTSLTSIYDLVL
PIEEEGEG

Download         Length: 747 bp

Antitoxin


Download         Length: 57 a.a.        Molecular weight: 6654.72 Da        Isoelectric Point: 11.0203

>AT254976 WP_003232646.1 NZ_CP103350:c1321426-1321256 [Bacillus subtilis]
MERAFQNRCEPRAAKPFKILKKRSTTSVASYQVSPHTARIFKENERLIDEYKRKKA

Download         Length: 171 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 3O6Q

Antitoxin

Source ID Structure
PDB 3O6Q
AlphaFold DB G4EXD8

References