Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-YafN
Location 80132..80654 Replicon plasmid p2
Accession NZ_CP103348
Organism Brucella anthropi strain CGMCC 1.17299

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NW321_RS24405 Protein ID WP_259030739.1
Coordinates 80132..80419 (-) Length 96 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag NW321_RS24410 Protein ID WP_128095071.1
Coordinates 80409..80654 (-) Length 82 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW321_RS24385 (NW321_24385) 75845..76858 + 1014 WP_259030735.1 zinc-binding dehydrogenase -
NW321_RS24390 (NW321_24390) 76917..77801 + 885 WP_259030736.1 transporter -
NW321_RS24395 (NW321_24395) 78416..78952 + 537 WP_259030737.1 hypothetical protein -
NW321_RS24400 (NW321_24400) 79166..80053 + 888 WP_259030738.1 zincin-like metallopeptidase domain-containing protein -
NW321_RS24405 (NW321_24405) 80132..80419 - 288 WP_259030739.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW321_RS24410 (NW321_24410) 80409..80654 - 246 WP_128095071.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
NW321_RS24415 (NW321_24415) 80815..81303 - 489 WP_139976380.1 helix-turn-helix transcriptional regulator -
NW321_RS24420 (NW321_24420) 81482..81859 - 378 WP_259030740.1 hypothetical protein -
NW321_RS24425 (NW321_24425) 81862..82287 - 426 WP_259030741.1 hypothetical protein -
NW321_RS24430 (NW321_24430) 82280..82993 - 714 WP_259030742.1 ParA family protein -
NW321_RS24435 (NW321_24435) 83555..83956 + 402 WP_259030647.1 MobC family plasmid mobilization relaxosome protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - - 1..165337 165337


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-81)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-76)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11012.83 Da        Isoelectric Point: 10.6834

>T254974 WP_259030739.1 NZ_CP103348:c80419-80132 [Brucella anthropi]
MPYKLEFLPSALKEWNKLGATIQQQLKKKLRERLETPRVVSASLHGMPDHYKIKLRQLGYRLVYSVNDDTVTVLVIAVGK
RERGDVYNTARSRTQ

Download         Length: 288 bp

Antitoxin


Download         Length: 82 a.a.        Molecular weight: 8930.25 Da        Isoelectric Point: 4.4217

>AT254974 WP_128095071.1 NZ_CP103348:c80654-80409 [Brucella anthropi]
MQRVEANIAVSVSDLKKSPSAVMDEANGEAVAVLNHNRIMAYMVPASVYEAMLEQLDDIRLTEIIRKRADEKGISVDIDA
L

Download         Length: 246 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References