Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1651762..1652393 Replicon chromosome
Accession NZ_CP103346
Organism Brucella anthropi strain CGMCC 1.17299

Toxin (Protein)


Gene name vapC Uniprot ID A0A256GHB5
Locus tag NW321_RS21780 Protein ID WP_029928525.1
Coordinates 1651762..1652163 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A256GGW7
Locus tag NW321_RS21785 Protein ID WP_010660354.1
Coordinates 1652163..1652393 (-) Length 77 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW321_RS21760 (NW321_21760) 1647199..1648719 - 1521 WP_151664370.1 FAD-dependent oxidoreductase -
NW321_RS21765 (NW321_21765) 1648849..1649790 - 942 WP_226622753.1 LysR substrate-binding domain-containing protein -
NW321_RS21770 (NW321_21770) 1649915..1651075 - 1161 WP_151616616.1 mandelate racemase/muconate lactonizing enzyme family protein -
NW321_RS21775 (NW321_21775) 1651104..1651358 - 255 WP_151664369.1 hypothetical protein -
NW321_RS21780 (NW321_21780) 1651762..1652163 - 402 WP_029928525.1 tRNA(fMet)-specific endonuclease VapC Toxin
NW321_RS21785 (NW321_21785) 1652163..1652393 - 231 WP_010660354.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
NW321_RS21790 (NW321_21790) 1652926..1653171 + 246 WP_010660453.1 type II toxin-antitoxin system CcdA family antitoxin -
NW321_RS21795 (NW321_21795) 1653171..1653467 + 297 WP_010660454.1 CcdB family protein -
NW321_RS21800 (NW321_21800) 1654304..1654930 + 627 WP_192798608.1 FliH/SctL family protein -
NW321_RS21805 (NW321_21805) 1655165..1656733 + 1569 Protein_1527 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-124)

Antitoxin

SpoVT-AbrB domain

(7-54)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 15055.14 Da        Isoelectric Point: 6.8629

>T254972 WP_029928525.1 NZ_CP103346:c1652163-1651762 [Brucella anthropi]
MLKYMLDTNICIFTIKNRPQQVREAFNRFHDQLCISSVSLMELIYGAEKSAHPEKNLAVVEGFAARLEVLSYDEPAANHT
GQLRAELARSGTPIGPYDQLIAGHARSRGLIIVTNNRREFDRVPGLRVEDWTD

Download         Length: 402 bp

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8487.53 Da        Isoelectric Point: 4.5045

>AT254972 WP_010660354.1 NZ_CP103346:c1652393-1652163 [Brucella anthropi]
MEQGAVFQSNRSQAIRLPKAVALPADVKRVDIVAVGRTRIIAPAGEVWDSWFDSLEATSDFMNERDQPAPQEREAF

Download         Length: 231 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A256GHB5

Antitoxin

Source ID Structure
AlphaFold DB A0A256GGW7

References