254971

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VapB
Location 1637901..1638475 Replicon chromosome
Accession NZ_CP103346
Organism Brucella anthropi strain CGMCC 1.17299

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NW321_RS21715 Protein ID WP_151576612.1
Coordinates 1638098..1638475 (+) Length 126 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A849KU45
Locus tag NW321_RS21710 Protein ID WP_010660355.1
Coordinates 1637901..1638101 (+) Length 67 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW321_RS21695 (NW321_21695) 1633521..1634114 - 594 WP_010660339.1 biliverdin-producing heme oxygenase -
NW321_RS21700 (NW321_21700) 1634165..1634848 - 684 WP_235693250.1 Crp/Fnr family transcriptional regulator -
NW321_RS21705 (NW321_21705) 1635156..1637690 + 2535 WP_151607226.1 HWE histidine kinase domain-containing protein -
NW321_RS21710 (NW321_21710) 1637901..1638101 + 201 WP_010660355.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NW321_RS21715 (NW321_21715) 1638098..1638475 + 378 WP_151576612.1 type II toxin-antitoxin system VapC family toxin Toxin
NW321_RS21720 (NW321_21720) 1638729..1639658 - 930 WP_151576611.1 LysR family transcriptional regulator -
NW321_RS21725 (NW321_21725) 1639769..1640473 + 705 WP_151607228.1 HAD-IA family hydrolase -
NW321_RS21730 (NW321_21730) 1640571..1641797 + 1227 WP_226622752.1 FAD-binding oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-110)

Antitoxin

Bacterial antitoxin of type II TA system, VapB

(1-42)


Sequences

Toxin        


Download         Length: 126 a.a.        Molecular weight: 13988.20 Da        Isoelectric Point: 7.0615

>T254971 WP_151576612.1 NZ_CP103346:1638098-1638475 [Brucella anthropi]
VILADTSIWIDHFRRGDNDLVKIIGNDLLLCHPAVIGELALGSLRDRTAVLTFLRAQRETIVATHDEVMTLIERHSVFSM
GIGYTDAHLLASVLLDQRTSLWTRDKRLKLAALKAGAALYEPFHN

Download         Length: 378 bp

Antitoxin


Download         Length: 67 a.a.        Molecular weight: 7162.26 Da        Isoelectric Point: 11.1107

>AT254971 WP_010660355.1 NZ_CP103346:1637901-1638101 [Brucella anthropi]
MRSTINLDDNLLEKARSLTGTKETAALVRQALEALVRVETGKRLIALGGTMPDAEAAPRRRSSVNK

Download         Length: 201 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A849KU45

References