Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) parDE/CC2985(antitoxin)
Location 1604216..1604762 Replicon chromosome
Accession NZ_CP103346
Organism Brucella anthropi strain CGMCC 1.17299

Toxin (Protein)


Gene name parE Uniprot ID -
Locus tag NW321_RS21500 Protein ID WP_151576736.1
Coordinates 1604216..1604509 (-) Length 98 a.a.

Antitoxin (Protein)


Gene name parD Uniprot ID A0A011V9B1
Locus tag NW321_RS21505 Protein ID WP_036586943.1
Coordinates 1604520..1604762 (-) Length 81 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW321_RS21485 (NW321_21485) 1600133..1601647 - 1515 WP_151607189.1 sugar ABC transporter ATP-binding protein -
NW321_RS21490 (NW321_21490) 1601740..1602693 - 954 WP_151576658.1 substrate-binding domain-containing protein -
NW321_RS21495 (NW321_21495) 1603030..1604004 + 975 WP_151576657.1 sugar-binding domain-containing protein -
NW321_RS21500 (NW321_21500) 1604216..1604509 - 294 WP_151576736.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NW321_RS21505 (NW321_21505) 1604520..1604762 - 243 WP_036586943.1 type II toxin-antitoxin system ParD family antitoxin Antitoxin
NW321_RS21510 (NW321_21510) 1605301..1605738 - 438 WP_080692061.1 IS5 family transposase -
NW321_RS21515 (NW321_21515) 1605991..1606434 + 444 WP_063620589.1 universal stress protein -
NW321_RS21520 (NW321_21520) 1606779..1607273 + 495 Protein_1470 divalent metal cation transporter -
NW321_RS21525 (NW321_21525) 1607194..1607478 + 285 WP_259030534.1 divalent metal cation transporter -
NW321_RS21530 (NW321_21530) 1607585..1609111 + 1527 WP_151652607.1 IS21 family transposase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-92)

Antitoxin

Antitoxin ParD

(2-77)


Sequences

Toxin        


Download         Length: 98 a.a.        Molecular weight: 11187.94 Da        Isoelectric Point: 5.5510

>T254970 WP_151576736.1 NZ_CP103346:c1604509-1604216 [Brucella anthropi]
MEFKLSVLAEDDIIAIAEQGIAMFGPVQAKRYHAELFNTLDLIANNPQIARAREEISPPVRVHPFKAHLIIYQIETDGMV
FVIRVRHAFEDWVRDPF

Download         Length: 294 bp

Antitoxin


Download         Length: 81 a.a.        Molecular weight: 8958.11 Da        Isoelectric Point: 5.7904

>AT254970 WP_036586943.1 NZ_CP103346:c1604762-1604520 [Brucella anthropi]
MVTMNVSLPHPMKEWVEAQAKTGRYSNASDYVRDLIRKDQMRSDKIAAMQRFVDEGLQSGPGSRSQDELFAVAVANAENL

Download         Length: 243 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A011V9B1

References