Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC(toxin)
Location 671776..672473 Replicon chromosome
Accession NZ_CP103345
Organism Brucella anthropi strain CGMCC 1.17299

Toxin (Protein)


Gene name vapC Uniprot ID A6WWK8
Locus tag NW321_RS03140 Protein ID WP_012090892.1
Coordinates 672045..672473 (+) Length 143 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A256H0E6
Locus tag NW321_RS03135 Protein ID WP_012090891.1
Coordinates 671776..672048 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW321_RS03115 (NW321_03115) 667466..668386 + 921 WP_012090886.1 glutathione ABC transporter permease GsiC -
NW321_RS03120 (NW321_03120) 668383..669267 + 885 WP_012090887.1 ABC transporter permease subunit -
NW321_RS03125 (NW321_03125) 669280..670098 + 819 WP_012090888.1 M55 family metallopeptidase -
NW321_RS03130 (NW321_03130) 670141..671076 + 936 WP_012090889.1 isoaspartyl peptidase/L-asparaginase -
NW321_RS03135 (NW321_03135) 671776..672048 + 273 WP_012090891.1 type II toxin-antitoxin system VapB family antitoxin Antitoxin
NW321_RS03140 (NW321_03140) 672045..672473 + 429 WP_012090892.1 type II toxin-antitoxin system VapC family toxin Toxin
NW321_RS03145 (NW321_03145) 672484..672792 - 309 WP_012090893.1 HigA family addiction module antitoxin -
NW321_RS03150 (NW321_03150) 673563..674870 + 1308 WP_259030354.1 IS1380 family transposase -
NW321_RS03155 (NW321_03155) 675065..676342 - 1278 WP_012090895.1 ABC transporter substrate-binding protein -
NW321_RS03160 (NW321_03160) 676384..677271 - 888 WP_259030355.1 carbohydrate ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 647369..729307 81938
- flank IS/Tn - - 673563..674870 1307


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-126)

Antitoxin

Antitoxin VapB-like

(1-79)


Sequences

Toxin        


Download         Length: 143 a.a.        Molecular weight: 15101.23 Da        Isoelectric Point: 4.4540

>T254969 WP_012090892.1 NZ_CP103345:672045-672473 [Brucella anthropi]
MMIVDASAIIAILFDEVEAPECMDALQSDTARLISAVNYVEAGTVLAGRIREGDRHAAIADLDAFLADFGILVASIDDRL
ARAAMKARVEYGKGFGTRAGLNFGDCFAYALAKRHSAPLLYVGDDFALTDIQSALSRGPCQG

Download         Length: 429 bp

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10588.79 Da        Isoelectric Point: 5.9303

>AT254969 WP_012090891.1 NZ_CP103345:671776-672048 [Brucella anthropi]
MALSIKTDEADRLARELSRLTGETMTDAITQAMRERLDRLRAEREAQRDYVARMKAFVRERASRYDRRPVTKQEWDEAVG
DTSEEPGYHQ

Download         Length: 273 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A6WWK8

Antitoxin

Source ID Structure
AlphaFold DB A0A256H0E6

References