254967

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 658566..659164 Replicon chromosome
Accession NZ_CP103345
Organism Brucella anthropi strain CGMCC 1.17299

Toxin (Protein)


Gene name brnT Uniprot ID -
Locus tag NW321_RS03060 Protein ID WP_158304319.1
Coordinates 658880..659164 (-) Length 95 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A256GNU9
Locus tag NW321_RS03055 Protein ID WP_041545288.1
Coordinates 658566..658880 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NW321_RS03040 (NW321_03040) 653999..657457 + 3459 WP_094514879.1 chromosome segregation protein SMC -
NW321_RS03045 (NW321_03045) 657562..657708 + 147 WP_158304318.1 hypothetical protein -
NW321_RS03050 (NW321_03050) 657738..657922 + 185 Protein_603 IS5/IS1182 family transposase -
NW321_RS03055 (NW321_03055) 658566..658880 - 315 WP_041545288.1 BrnA antitoxin family protein Antitoxin
NW321_RS03060 (NW321_03060) 658880..659164 - 285 WP_158304319.1 hypothetical protein Toxin
NW321_RS03065 (NW321_03065) 659343..660524 + 1182 WP_012090877.1 Fic family protein -
NW321_RS03070 (NW321_03070) 660801..660959 + 159 WP_259030353.1 PIN domain-containing protein -
NW321_RS03075 (NW321_03075) 660956..661210 + 255 WP_125301843.1 toxin-antitoxin system HicB family antitoxin -
NW321_RS03080 (NW321_03080) 661512..661938 + 427 Protein_609 type IV secretory system conjugative DNA transfer family protein -
NW321_RS03085 (NW321_03085) 662093..662425 - 333 WP_012090880.1 type II toxin-antitoxin system HicB family antitoxin -
NW321_RS03090 (NW321_03090) 662422..662676 - 255 WP_040129739.1 type II toxin-antitoxin system HicA family toxin -
NW321_RS03095 (NW321_03095) 662690..662965 - 276 WP_235915181.1 hypothetical protein -
NW321_RS03100 (NW321_03100) 663108..664001 + 894 WP_012090883.1 MurR/RpiR family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Integrative and Conjugative Element - - 647369..729307 81938


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(28-102)


Sequences

Toxin        


Download         Length: 95 a.a.        Molecular weight: 10840.76 Da        Isoelectric Point: 10.8134

>T254967 WP_158304319.1 NZ_CP103345:c659164-658880 [Brucella anthropi]
MSQSVEFMLLKTQWYLSRNWIRAKWKTGSNSIETQHLHLEFFLSAKVFPTKADRLMAIGEFNGQIIIVVVFKPIGSEALS
VISMRPASQKERKL

Download         Length: 285 bp

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 11605.44 Da        Isoelectric Point: 10.3131

>AT254967 WP_041545288.1 NZ_CP103345:c658880-658566 [Brucella anthropi]
MGIKFSSKRPLTQEEEAAIQKMIASDPDAPEATDEQLAKAKPFKEALPEMAAKMEKAIRGRPRIDDPKTPVTIRLDQDVV
QRFKATGKGWQSRMNEALRKAVGL

Download         Length: 315 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A256GNU9

References