254965

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) BrnTA/BrnT-BrnA
Location 2512..3097 Replicon plasmid unnamed4
Accession NZ_CP103341
Organism Acinetobacter baumannii strain AB105

Toxin (Protein)


Gene name brnT Uniprot ID A0A158LPL9
Locus tag NT399_RS18250 Protein ID WP_002124950.1
Coordinates 2512..2799 (+) Length 96 a.a.

Antitoxin (Protein)


Gene name brnA Uniprot ID A0A158LPT9
Locus tag NT399_RS18255 Protein ID WP_004836815.1
Coordinates 2786..3097 (+) Length 104 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NT399_RS18230 (NT399_18230) 1..933 + 933 WP_002124966.1 replication initiation protein RepM -
NT399_RS18235 (NT399_18235) 993..1553 + 561 WP_223154292.1 plasmid replication DNA-binding protein -
NT399_RS18240 (NT399_18240) 1566..1709 + 144 WP_001125247.1 hypothetical protein -
NT399_RS18245 (NT399_18245) 1899..2282 + 384 WP_038343695.1 hypothetical protein -
NT399_RS18250 (NT399_18250) 2512..2799 + 288 WP_002124950.1 BrnT family toxin Toxin
NT399_RS18255 (NT399_18255) 2786..3097 + 312 WP_004836815.1 BrnA antitoxin family protein Antitoxin
NT399_RS18260 (NT399_18260) 3204..3665 - 462 WP_002124952.1 hypothetical protein -
NT399_RS18265 (NT399_18265) 3658..4359 - 702 WP_002124954.1 serine protease -
NT399_RS18270 (NT399_18270) 4536..4808 - 273 WP_002126333.1 NadS family protein -
NT399_RS18275 (NT399_18275) 4801..5121 - 321 WP_002126330.1 type II toxin-antitoxin system RelE/ParE family toxin -
NT399_RS18280 (NT399_18280) 5293..5721 + 429 WP_002125445.1 hypothetical protein -
NT399_RS18285 (NT399_18285) 5787..5978 - 192 WP_002125028.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Non-Mobilizable plasmid - katA 1..13439 13439


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Ribonuclease toxin, BrnT, of type II toxin-antitoxin system

(7-88)

Antitoxin

BrnA antitoxin of type II toxin-antitoxin system

(41-96)


Sequences

Toxin        


Download         Length: 96 a.a.        Molecular weight: 11173.58 Da        Isoelectric Point: 4.9093

>T254965 WP_002124950.1 NZ_CP103341:2512-2799 [Acinetobacter baumannii]
MELYFEWDEAKNQKNQKKHDVSFETASLVFEDPLRISIQDRHTNGEERWQTIGMVKGVLMLLVAHTIIDDDDCEIIRIIS
ARQVTKAERNQYEHG

Download         Length: 288 bp

Antitoxin


Download         Length: 104 a.a.        Molecular weight: 12056.73 Da        Isoelectric Point: 8.5036

>AT254965 WP_004836815.1 NZ_CP103341:2786-3097 [Acinetobacter baumannii]
MSMVRYTRKELNENFSDKQDAEIKRLLAKGTVPDEQLDLSDIPEITDWSHAVRHGQFYRPVKQQTSVRLDADVLAWLKAQ
GKGYQTRMNKILREAMLEDLKNH

Download         Length: 312 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A158LPL9

Antitoxin

Source ID Structure
AlphaFold DB A0A158LPT9

References