Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 1981..2540 Replicon plasmid p3
Accession NZ_CP103332
Organism Escherichia coli strain ZY22049

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag NX000_RS25570 Protein ID WP_078165295.1
Coordinates 2265..2540 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID U9Y625
Locus tag NX000_RS25565 Protein ID WP_001178087.1
Coordinates 1981..2265 (+) Length 95 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX000_RS25560 (46) 46..1077 + 1032 WP_272592198.1 plasmid replication initiator RepA -
NX000_RS25565 (1981) 1981..2265 + 285 WP_001178087.1 ribbon-helix-helix domain-containing protein Antitoxin
NX000_RS25570 (2265) 2265..2540 + 276 WP_078165295.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
NX000_RS25575 (2646) 2646..2849 + 204 Protein_3 hypothetical protein -
NX000_RS25580 (3119) 3119..3385 - 267 WP_000627832.1 hypothetical protein -
NX000_RS25585 (3385) 3385..3879 - 495 WP_015058884.1 hypothetical protein -
NX000_RS25590 (3935) 3935..4537 - 603 WP_000521606.1 ProQ/FINO family protein -
NX000_RS25595 (4713) 4713..5765 - 1053 WP_000655519.1 hypothetical protein -
NX000_RS25600 (5978) 5978..6568 - 591 WP_001401589.1 hypothetical protein -
NX000_RS25605 (6568) 6568..6822 - 255 WP_000343106.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Conjugative plasmid - - 1..85443 85443


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(14-51)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10764.50 Da        Isoelectric Point: 9.9324

>T254956 WP_078165295.1 NZ_CP103332:2265-2540 [Escherichia coli]
MELKWTSKALSDLARLYDFLVLASKPAAVRTVQSLTQAPVILLTHPRMGEQLFQFEPREVRRIFAGEYEIRYELTGQTIY
VLRLWHTRENR

Download         Length: 276 bp

Antitoxin


Download         Length: 95 a.a.        Molecular weight: 10488.92 Da        Isoelectric Point: 5.6558

>AT254956 WP_001178087.1 NZ_CP103332:1981-2265 [Escherichia coli]
MQMKNNTAQATKVITAHVPLPMADKVDQMAARLERSRGWIIKQALSAWLAQEEERNRLTLEALDDVTSGQVIDHQAVQAW
ADSLSTDNPLPVPR

Download         Length: 285 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB U9Y625

References