Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) tacAT/DUF1778(antitoxin)
Location 1504456..1505198 Replicon chromosome
Accession NC_015761
Organism Salmonella bongori NCTC 12419

Toxin (Protein)


Gene name tacT Uniprot ID A0A248K916
Locus tag SBG_RS07125 Protein ID WP_000521216.1
Coordinates 1504456..1504944 (-) Length 163 a.a.

Antitoxin (Protein)


Gene name tacA Uniprot ID S5MPV7
Locus tag SBG_RS07130 Protein ID WP_020844238.1
Coordinates 1504932..1505198 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBG_RS07105 1500144..1501652 - 1509 WP_000196705.1 FAD-dependent oxidoreductase -
SBG_RS07110 1501697..1502185 + 489 WP_001293644.1 MarR family winged helix-turn-helix transcriptional regulator -
SBG_RS07115 1502362..1503441 + 1080 WP_000954703.1 S-adenosylmethionine:tRNA ribosyltransferase-isomerase -
SBG_RS07120 1503509..1503898 - 390 WP_015702869.1 RidA family protein -
SBG_RS07125 1504456..1504944 - 489 WP_000521216.1 GNAT family N-acetyltransferase Toxin
SBG_RS07130 1504932..1505198 - 267 WP_020844238.1 DUF1778 domain-containing protein Antitoxin
SBG_RS07135 1505313..1507388 - 2076 WP_000210608.1 glycogen debranching protein GlgX -
SBG_RS07140 1507431..1509959 - 2529 WP_000613169.1 malto-oligosyltrehalose synthase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(32-151)

Antitoxin

Vibrio phage ICP1, Orf50

(4-87)


Sequences

Toxin        


Download         Length: 163 a.a.        Molecular weight: 17719.47 Da        Isoelectric Point: 9.5852

>T25495 WP_000521216.1 NC_015761:c1504944-1504456 [Salmonella bongori NCTC 12419]
VGKVTAPAPLSTLHNLAEFCCGESLLDDWLRQRALKNQATGASRTFVVCKAASHQVVGFYSLATGSVNHAEATGGLRRNM
PDPIPVIILARLAVDVSYHGIGLGADLLRDAILRAYRVAENIGVRAMVVQALTEQAKRFYLHHGFRESGKQERTLFLILP
ER

Download         Length: 489 bp

>T25495 NC_015761:c1504944-1504456 [Salmonella bongori NCTC 12419]
GTGGGAAAAGTAACCGCGCCTGCACCGTTATCCACGCTGCATAACCTGGCGGAATTCTGCTGCGGTGAAAGTCTGTTAGA
CGACTGGCTGCGGCAACGTGCGTTAAAAAACCAGGCGACTGGCGCATCCAGAACTTTTGTGGTGTGCAAAGCCGCCAGCC
ATCAGGTCGTTGGGTTTTATTCGCTGGCAACGGGCAGCGTTAATCACGCTGAAGCGACGGGCGGTTTGCGCCGCAATATG
CCCGATCCAATTCCGGTCATTATCCTGGCGCGTCTGGCTGTAGATGTGTCTTATCATGGAATCGGGCTGGGCGCGGATTT
ATTGCGCGATGCCATATTACGCGCGTATCGGGTGGCGGAAAATATCGGCGTTCGGGCGATGGTGGTGCAAGCGTTAACAG
AACAGGCTAAACGCTTCTATCTGCATCATGGTTTTCGGGAATCAGGTAAGCAAGAGAGGACGCTATTTCTTATCCTTCCG
GAAAGATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 9999.47 Da        Isoelectric Point: 4.7961

>AT25495 WP_020844238.1 NC_015761:c1505198-1504932 [Salmonella bongori NCTC 12419]
MKSGVQLNIRAKESQRALIDTAAEILHKSRTDFILEMACQAAENVILDRRVFNLNDDQYAEFVEMLDAPVATNPALDNLL
ARKPLWEK

Download         Length: 267 bp

>AT25495 NC_015761:c1505198-1504932 [Salmonella bongori NCTC 12419]
ATGAAATCAGGCGTTCAACTCAATATTCGGGCCAAAGAGTCACAGCGGGCGTTAATCGATACGGCGGCCGAGATTCTGCA
TAAATCACGAACCGACTTTATCCTTGAAATGGCTTGCCAGGCAGCCGAAAACGTTATTCTGGATCGCCGGGTATTTAACC
TTAACGACGATCAATACGCCGAGTTTGTTGAAATGCTTGATGCGCCTGTTGCTACAAATCCGGCGCTGGATAACTTACTG
GCGAGAAAACCACTGTGGGAAAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A248K916

Antitoxin

Source ID Structure
AlphaFold DB S5MPV7

References