Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3532350..3532968 Replicon chromosome
Accession NZ_CP103329
Organism Escherichia coli strain ZY22049

Toxin (Protein)


Gene name Hha Uniprot ID H5UYE2
Locus tag NX000_RS17400 Protein ID WP_001291435.1
Coordinates 3532750..3532968 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID S1PTH5
Locus tag NX000_RS17395 Protein ID WP_000344800.1
Coordinates 3532350..3532724 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX000_RS17385 (3527439) 3527439..3528632 + 1194 WP_001295324.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
NX000_RS17390 (3528655) 3528655..3531804 + 3150 WP_001132469.1 efflux RND transporter permease AcrB -
NX000_RS17395 (3532350) 3532350..3532724 + 375 WP_000344800.1 Hha toxicity modulator TomB Antitoxin
NX000_RS17400 (3532750) 3532750..3532968 + 219 WP_001291435.1 HHA domain-containing protein Toxin
NX000_RS17405 (3533140) 3533140..3533691 + 552 WP_000102568.1 maltose O-acetyltransferase -
NX000_RS17410 (3533807) 3533807..3534277 + 471 WP_000136192.1 YlaC family protein -
NX000_RS17415 (3534441) 3534441..3535991 + 1551 WP_001372022.1 cyclic-guanylate-specific phosphodiesterase PdeB -
NX000_RS17420 (3536033) 3536033..3536386 - 354 WP_000878140.1 DUF1428 domain-containing protein -
NX000_RS17430 (3536765) 3536765..3537076 + 312 WP_000409911.1 MGMT family protein -
NX000_RS17435 (3537107) 3537107..3537679 - 573 WP_000779831.1 YbaY family lipoprotein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-117)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8628.00 Da        Isoelectric Point: 8.9008

>T254945 WP_001291435.1 NZ_CP103329:3532750-3532968 [Escherichia coli]
MSEKPLTKTDYLMRLRRCQTIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPSSVWKFIR

Download         Length: 219 bp

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14557.39 Da        Isoelectric Point: 4.7395

>AT254945 WP_000344800.1 NZ_CP103329:3532350-3532724 [Escherichia coli]
MDEYSPKRHDIAQLKFLCETLYHDCLANLEESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINMQDLQKWRKSGNRLFRCFVNATKENPASLSC

Download         Length: 375 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
PDB 2MW2
PDB 1JW2

Antitoxin

Source ID Structure
AlphaFold DB A0A7U9QBQ5

References