Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 1335858..1336483 Replicon chromosome
Accession NZ_CP103329
Organism Escherichia coli strain ZY22049

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag NX000_RS06520 Protein ID WP_000911330.1
Coordinates 1336085..1336483 (+) Length 133 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID U9XQV3
Locus tag NX000_RS06515 Protein ID WP_000450524.1
Coordinates 1335858..1336085 (+) Length 76 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX000_RS06490 (1331661) 1331661..1332131 - 471 WP_001068682.1 thioredoxin-dependent thiol peroxidase -
NX000_RS06495 (1332131) 1332131..1332703 - 573 WP_000176187.1 glycine cleavage system transcriptional repressor -
NX000_RS06500 (1332849) 1332849..1333727 + 879 WP_001295469.1 4-hydroxy-tetrahydrodipicolinate synthase -
NX000_RS06505 (1333744) 1333744..1334778 + 1035 WP_001297320.1 outer membrane protein assembly factor BamC -
NX000_RS06510 (1334991) 1334991..1335704 + 714 WP_001295467.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
NX000_RS06515 (1335858) 1335858..1336085 + 228 WP_000450524.1 toxin-antitoxin system antitoxin VapB Antitoxin
NX000_RS06520 (1336085) 1336085..1336483 + 399 WP_000911330.1 type II toxin-antitoxin system VapC family toxin Toxin
NX000_RS06525 (1336630) 1336630..1337493 + 864 WP_001267507.1 neutral zinc metallopeptidase -
NX000_RS06530 (1337508) 1337508..1339523 + 2016 WP_000829323.1 tRNA cytosine(34) acetyltransferase TmcA -
NX000_RS06535 (1339597) 1339597..1340295 + 699 WP_000679823.1 esterase -
NX000_RS06540 (1340405) 1340405..1340605 - 201 WP_000383836.1 YpfN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(5-125)

Antitoxin

SpoVT-AbrB domain

(7-52)


Sequences

Toxin        


Download         Length: 133 a.a.        Molecular weight: 14894.25 Da        Isoelectric Point: 9.2216

>T254938 WP_000911330.1 NZ_CP103329:1336085-1336483 [Escherichia coli]
MLKFMLDTNICIFTIKNKPVHVRERFNLNSGRMCISSVTLMELIYGAEKSQMPERNLAVIEGFVSRLVVLDYDSAAATHT
GQIRAELARQGRPVGPFDQMIAGHARSRGLIVVTNNTREFERVAGIRLEDWS

Download         Length: 399 bp

Antitoxin


Download         Length: 76 a.a.        Molecular weight: 8498.61 Da        Isoelectric Point: 4.3867

>AT254938 WP_000450524.1 NZ_CP103329:1335858-1336085 [Escherichia coli]
METTVFLSNRSQAVRLPKAVALPEDVKKVEIIAIGRTRIITPAGESWDSWFDGENVSADFMDIRDQPAMQERESF

Download         Length: 228 bp


Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure
AlphaFold DB A0A829CM33

References