Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 894818..895472 Replicon chromosome
Accession NZ_CP103329
Organism Escherichia coli strain ZY22049

Toxin (Protein)


Gene name cptA Uniprot ID S1EEB2
Locus tag NX000_RS04415 Protein ID WP_000244777.1
Coordinates 895065..895472 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID S1PPB1
Locus tag NX000_RS04410 Protein ID WP_000354046.1
Coordinates 894818..895084 (+) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX000_RS04385 (890106) 890106..890849 + 744 Protein_860 SDR family oxidoreductase -
NX000_RS04390 (890906) 890906..892339 - 1434 WP_001363803.1 6-phospho-beta-glucosidase BglA -
NX000_RS04395 (892384) 892384..892695 + 312 WP_001679467.1 N(4)-acetylcytidine aminohydrolase -
NX000_RS04400 (892859) 892859..893518 + 660 WP_000250274.1 hemolysin III family protein -
NX000_RS04405 (893595) 893595..894575 - 981 WP_000886062.1 tRNA-modifying protein YgfZ -
NX000_RS04410 (894818) 894818..895084 + 267 WP_000354046.1 FAD assembly factor SdhE Antitoxin
NX000_RS04415 (895065) 895065..895472 + 408 WP_000244777.1 protein YgfX Toxin
NX000_RS04420 (895512) 895512..896033 - 522 WP_001055874.1 flavodoxin FldB -
NX000_RS04425 (896145) 896145..897041 + 897 WP_000806638.1 site-specific tyrosine recombinase XerD -
NX000_RS04430 (897066) 897066..897776 + 711 WP_000715214.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
NX000_RS04435 (897782) 897782..899515 + 1734 WP_000813212.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(3-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 136 a.a.        Molecular weight: 16031.96 Da        Isoelectric Point: 11.5202

>T254935 WP_000244777.1 NZ_CP103329:895065-895472 [Escherichia coli]
VVLWQSDLRVSWRAQWLSLLIHGLVAAVILLMPWPLSYTPLWMVLLSLVVFDCVRSQRRINARQGEIRLLMDGRLRWQGQ
EWSIVKAPWMIKSGMMLRLRSDGGKRQHLWLAADSMDEAEWRDLRRILLQQETQR

Download         Length: 408 bp


Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10547.12 Da        Isoelectric Point: 5.1599

>AT254935 WP_000354046.1 NZ_CP103329:894818-895084 [Escherichia coli]
MDINNKARIHWACRRGMRELDISIMPFFEHEYDSLSDDEKRIFIRLLECDDPDLFNWLMNHGKPADAELEMMVRLIQTRN
RERGPVAI

Download         Length: 267 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A7U9LFV7


Antitoxin

Source ID Structure
PDB 6B58
PDB 1X6I
PDB 1X6J
PDB 6C12
AlphaFold DB A0A7U9QD57

References