Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) hicAB/-
Location 298218..298804 Replicon chromosome
Accession NZ_CP103329
Organism Escherichia coli strain ZY22049

Toxin (Protein)


Gene name hicA Uniprot ID A0A0H0RQZ4
Locus tag NX000_RS01355 Protein ID WP_042014162.1
Coordinates 298218..298448 (+) Length 77 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID U9Y7E1
Locus tag NX000_RS01360 Protein ID WP_000593555.1
Coordinates 298445..298804 (+) Length 120 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
NX000_RS01345 (294255) 294255..296990 + 2736 WP_000149132.1 ribosome-associated ATPase/putative transporter RbbA -
NX000_RS01350 (296990) 296990..298114 + 1125 WP_001314210.1 ABC transporter permease -
NX000_RS01355 (298218) 298218..298448 + 231 WP_042014162.1 type II toxin-antitoxin system HicA family toxin Toxin
NX000_RS01360 (298445) 298445..298804 + 360 WP_000593555.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
NX000_RS01365 (298924) 298924..299325 - 402 WP_001190062.1 nickel-responsive transcriptional regulator NikR -
NX000_RS01370 (299331) 299331..300137 - 807 WP_000173666.1 nickel import ATP-binding protein NikE -
NX000_RS01375 (300134) 300134..300898 - 765 WP_001136236.1 nickel import ATP-binding protein NikD -
NX000_RS01380 (300898) 300898..301731 - 834 WP_001008963.1 nickel ABC transporter permease subunit NikC -
NX000_RS01385 (301728) 301728..302672 - 945 WP_000947068.1 nickel ABC transporter permease subunit NikB -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(15-65)

Antitoxin

(60-112)


Sequences


Toxin        


Download         Length: 77 a.a.        Molecular weight: 8419.79 Da        Isoelectric Point: 8.5518

>T254931 WP_042014162.1 NZ_CP103329:298218-298448 [Escherichia coli]
MDQLFKSPLPQGIKWTDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESVRDWLLSIGVKP

Download         Length: 231 bp


Antitoxin


Download         Length: 120 a.a.        Molecular weight: 13402.27 Da        Isoelectric Point: 5.1987

>AT254931 WP_000593555.1 NZ_CP103329:298445-298804 [Escherichia coli]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL

Download         Length: 360 bp


Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure
AlphaFold DB A0A0H0RQZ4


Antitoxin

Source ID Structure
AlphaFold DB A0A7U9LKZ6

References