Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 298218..298804 | Replicon | chromosome |
Accession | NZ_CP103329 | ||
Organism | Escherichia coli strain ZY22049 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | A0A0H0RQZ4 |
Locus tag | NX000_RS01355 | Protein ID | WP_042014162.1 |
Coordinates | 298218..298448 (+) | Length | 77 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | U9Y7E1 |
Locus tag | NX000_RS01360 | Protein ID | WP_000593555.1 |
Coordinates | 298445..298804 (+) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
NX000_RS01345 (294255) | 294255..296990 | + | 2736 | WP_000149132.1 | ribosome-associated ATPase/putative transporter RbbA | - |
NX000_RS01350 (296990) | 296990..298114 | + | 1125 | WP_001314210.1 | ABC transporter permease | - |
NX000_RS01355 (298218) | 298218..298448 | + | 231 | WP_042014162.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
NX000_RS01360 (298445) | 298445..298804 | + | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
NX000_RS01365 (298924) | 298924..299325 | - | 402 | WP_001190062.1 | nickel-responsive transcriptional regulator NikR | - |
NX000_RS01370 (299331) | 299331..300137 | - | 807 | WP_000173666.1 | nickel import ATP-binding protein NikE | - |
NX000_RS01375 (300134) | 300134..300898 | - | 765 | WP_001136236.1 | nickel import ATP-binding protein NikD | - |
NX000_RS01380 (300898) | 300898..301731 | - | 834 | WP_001008963.1 | nickel ABC transporter permease subunit NikC | - |
NX000_RS01385 (301728) | 301728..302672 | - | 945 | WP_000947068.1 | nickel ABC transporter permease subunit NikB | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A0H0RQZ4 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LKZ6 |